Unraveling innate substrate control in site-selective palladium-catalyzed C–H heterocycle functionalization
Keyword(s):
Pd(ii)-catalyzed direct arylation of chromones and enaminones gives divergent site-selectivities. Computational and experimental studies reveal a switch in mechanism, from a C3-selective CMD mechanism to a C2-selective carbopalladation pathway. This model accounts for the opposite selectivities of enaminone and chromone, and also correctly predicts selectivities for the C–H functionalization of heteroaromatic substrates as a function of the coupling partner.
2017 ◽
Keyword(s):
2017 ◽
2008 ◽
Vol 73
(22)
◽
pp. 9164-9167
◽