Catalytic asymmetric aldol addition reactions of 3-fluoro-indolinone derived enolates

2017 ◽  
Vol 15 (2) ◽  
pp. 311-315 ◽  
Author(s):  
Lijun Zhang ◽  
Wenzhong Zhang ◽  
Haibo Mei ◽  
Jianlin Han ◽  
Vadim A. Soloshonok ◽  
...  
Keyword(s):  
Aldol Reactions ◽  
Addition Reactions ◽  
Asymmetric Aldol ◽  
Wide Range ◽  
Stereogenic Centers ◽  
New Type ◽  
Catalytic Asymmetric ◽  
Aldol Addition ◽  
Quaternary Stereogenic Centers

Cu(i)/bisoxazoline ligand catalyzed asymmetric aldol reactions of fluoro-indolinone derived new type tertiary enolates have been developed. This process allows the preparation of a wide range of α-fluoro-β-aryl/hetaryl/alkyl-β-hydroxy-indolin-2-one products containing C–F quaternary stereogenic centers.

scholarly journals Asymmetric Synthetic Strategies of (R)-(–)-Baclofen: An Antispastic Drug

Synthesis ◽  
2017 ◽  
Vol 50 (02) ◽  
pp. 211-226 ◽  
Author(s):  
Perla Ramesh ◽  
Devatha Suman ◽  
Koti Reddy
Keyword(s):  
Asymmetric Reduction ◽  
Asymmetric Hydrogenation ◽  
Asymmetric Aldol ◽  
Asymmetric Michael Addition ◽  
Chemical Resolution ◽  
Enzymatic Desymmetrization ◽  
Catalytic Asymmetric ◽  
Aldol Addition ◽  
Synthetic Approaches ◽  
Catalytic Asymmetric Hydrogenation

Baclofen is an antispastic drug used as a muscle relaxant in the treatment of the paroxysmal pain of trigeminal neuralgia, spasticity of the spinal cord and cerebral origin. Baclofen resides biological activity exclusively in its (R)-(–)-enantiomer. In this review, various asymmetric synthetic strategies for (R)-(–)-baclofen are described.1 Introduction2 Resolution Synthetic Approaches2.1 Chemical Resolution2.2 Biocatalytic Resolution3 Asymmetric Desymmetrization3.1 Catalytic Enantioselective Desymmetrization3.2 Enzymatic Desymmetrization4 Chiral Auxiliary Induced Asymmetric Synthesis4.1 Asymmetric Michael Addition4.2 Asymmetric Aldol Addition4.3 Asymmetric Nucleophilic Substitution5 Asymmetric Reduction5.1 Catalytic Asymmetric Hydrogenation5.2 Bioreduction6 Catalytic Asymmetric Conjugate Addition7 Conclusion

Catalytic asymmetric aldol reactions in water

1999 ◽  
Vol 1 (4) ◽  
pp. 175-177 ◽  
Author(s):  
Shū Kobayashi ◽  
Yuichiro Mori ◽  
Satoshi Nagayama ◽  
Kei Manabe
Keyword(s):  
Aldol Reactions ◽  
Asymmetric Aldol ◽  
Catalytic Asymmetric

scholarly journals Catalytic Asymmetric Aldol Reactions in Aqueous Media Using Chiral Bis-pyridino-18-crown-6—Rare Earth Metal Triflate Complexes.

ChemInform ◽  
2003 ◽  
Vol 34 (28) ◽  
Author(s):  
Tomoaki Hamada ◽  
Kei Manabe ◽  
Shunpei Ishikawa ◽  
Satoshi Nagayama ◽  
Motoo Shiro ◽  
...  
Keyword(s):  
Rare Earth ◽  
Rare Earth Metal ◽  
Aqueous Media ◽  
Earth Metal ◽  
Aldol Reactions ◽  
Asymmetric Aldol ◽  
Catalytic Asymmetric

scholarly journals Catalytic Asymmetric Aldol Reactions in Aqueous Media

2003 ◽  
Vol 61 (5) ◽  
pp. 445-453 ◽  
Author(s):  
Tomoaki Hamada ◽  
Kei Manabe ◽  
Shu Kobayashi
Keyword(s):  
Aqueous Media ◽  
Aldol Reactions ◽  
Asymmetric Aldol ◽  
Catalytic Asymmetric
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