Molecular sieve mediated sequential Knoevenagel condensation/decarboxylative Michael addition reaction: efficient and mild conditions for the synthesis of 3,3-disubstituted oxindoles with an all carbon quaternary center

RSC Advances ◽  
2016 ◽  
Vol 6 (78) ◽  
pp. 74683-74690 ◽  
Author(s):  
Yi-Lin Guo ◽  
Yu-Hsun Li ◽  
Hsuan-Hao Chang ◽  
Ting-Shen Kuo ◽  
Jeng-Liang Han
Keyword(s):  
Michael Addition ◽  
Molecular Sieve ◽  
Addition Reaction ◽  
Knoevenagel Condensation ◽  
Michael Addition Reaction ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Quaternary Center ◽  
Broad Scope

A mild, catalyst-free and efficient molecular sieve mediated sequential Knoevenagel condensation/decarboxylative Michael additon reaction has been developed. A broad scope of 3,3-disubstituted oxindoles were synthesized in good to excellent yields.

Water-prompted synthesis of alkyl nitrile derivatives via Knoevenagel condensation and Michael addition reaction

2011 ◽  
Vol 13 (3) ◽  
pp. 566 ◽  
Author(s):  
Ebrahim Soleimani ◽  
Mohammad Mehdi Khodaei ◽  
Nasim Batooie ◽  
Mostafa Baghbanzadeh
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Knoevenagel Condensation ◽  
Michael Addition Reaction

Synthesis of functionalized isoxazole–oxindole hybrids via on water, catalyst free vinylogous Henry and 1,6-Michael addition reactions

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 81768-81773 ◽  
Author(s):  
Sakkani Nagaraju ◽  
Neeli Satyanarayana ◽  
Banoth Paplal ◽  
Anuji K. Vasu ◽  
Sriram Kanvah ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Addition Reactions ◽  
Michael Addition Reaction ◽  
Henry Reaction ◽  
Catalyst Free

Various isoxazole–oxindole hybrids were synthesized via vinylogous Henry reaction of 3,5-dimethyl-4-nitroisoxazole and isatin under catalyst free conditions in water. The products obtained were functionalized using 1,6-Michael addition reaction.

Squaramide-catalysed asymmetric cascade aza-Michael/Michael addition reaction for the synthesis of chiral trisubstituted pyrrolidines

2015 ◽  
Vol 13 (46) ◽  
pp. 11351-11361 ◽  
Author(s):  
Bo-Liang Zhao ◽  
Ye Lin ◽  
Hao-Hao Yan ◽  
Da-Ming Du
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Cascade Reaction ◽  
Michael Addition Reaction ◽  
Mild Conditions

A squaramide catalysed aza-Michael/Michael cascade reaction between nitroalkenes and tosylaminomethyl enones or enoates afforded highly functionalized chiral pyrrolidines in good yields (up to 99%) with good diastereoselectivities (up to 91 : 9 dr) and excellent enantioselectivities (up to >99% ee) under mild conditions.

scholarly journals Imidazolyl activated carbon refluxed with ethanediamine as reusable heterogeneous catalysts for Michael addition

RSC Advances ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 185-191
Author(s):  
Wenzhu Liu ◽  
Jiafu Xiao ◽  
Qiong Xu ◽  
Xianxiang Liu ◽  
Sheng Zhong ◽  
...  
Keyword(s):  
Activated Carbon ◽  
Michael Addition ◽  
Heterogeneous Catalysts ◽  
Addition Reaction ◽  
Catalytic Performance ◽  
Michael Addition Reaction ◽  
Mild Conditions ◽  
Excellent Catalytic Performance

Imidazolyl activated carbon was prepared under mild conditions and showed excellent catalytic performance in Michael addition reaction.

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