Synthesis of functionalized isoxazole–oxindole hybrids via on water, catalyst free vinylogous Henry and 1,6-Michael addition reactions

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 81768-81773 ◽  
Author(s):  
Sakkani Nagaraju ◽  
Neeli Satyanarayana ◽  
Banoth Paplal ◽  
Anuji K. Vasu ◽  
Sriram Kanvah ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Addition Reactions ◽  
Michael Addition Reaction ◽  
Henry Reaction ◽  
Catalyst Free

Various isoxazole–oxindole hybrids were synthesized via vinylogous Henry reaction of 3,5-dimethyl-4-nitroisoxazole and isatin under catalyst free conditions in water. The products obtained were functionalized using 1,6-Michael addition reaction.

Synthesis of pyrrolidine-3-carboxylic acid derivatives via asymmetric Michael addition reactions of carboxylate-substituted enones

2017 ◽  
Vol 15 (29) ◽  
pp. 6089-6092 ◽  
Author(s):  
Feng Yin ◽  
Ainash Garifullina ◽  
Fujie Tanaka
Keyword(s):  
Carboxylic Acid ◽  
Michael Addition ◽  
Addition Reaction ◽  
Reaction System ◽  
Addition Reactions ◽  
Michael Addition Reaction ◽  
Asymmetric Michael Addition

An enantioselective Michael addition reaction system was developed. Using the reaction system, 5-methylpyrrolidine-3-carboxylic acid was synthesized in two steps.

Preparation of a chiral Pt12 tetrahedral cage and its use in catalytic Michael addition reaction

2018 ◽  
Vol 54 (38) ◽  
pp. 4814-4817 ◽  
Author(s):  
Imtiyaz Ahmad Bhat ◽  
Anthonisamy Devaraj ◽  
Prodip Howlader ◽  
Ki-Whan Chi ◽  
Partha Sarathi Mukherjee
Keyword(s):  
Michael Addition ◽  
Self Assembly ◽  
Addition Reaction ◽  
Addition Reactions ◽  
Stoichiometric Ratio ◽  
Michael Addition Reaction ◽  
Methanol Mixture ◽  
Hexadentate Ligand ◽  
The Michael Addition

A chiral M12L4 molecular tetrahedron (T) was synthesized by self-assembly of chiral cis-[(1S,2S)-dch]Pt(NO3)2 (M) with a hexadentate ligand (L) in 3 : 1 stoichiometric ratio. The cage T was found to catalyze the Michael addition reactions of series of nitrostyrene derivatives with indole in (9 : 1) water–methanol mixture.

Theoretical free energy profile and benchmarking of functionals for amino-thiourea organocatalyzed nitro-Michael addition reaction

2020 ◽  
Vol 22 (20) ◽  
pp. 11529-11536 ◽  
Author(s):  
Josefredo R. Pliego
Keyword(s):  
Free Energy ◽  
Michael Addition ◽  
Addition Reaction ◽  
Conjugate Addition ◽  
Catalytic Process ◽  
Addition Reactions ◽  
Energy Profile ◽  
Michael Addition Reaction ◽  
Free Energy Profile

Amino-thiourea organocatalysis is an important catalytic process for enantioselective conjugate addition reactions.

Molecular sieve mediated sequential Knoevenagel condensation/decarboxylative Michael addition reaction: efficient and mild conditions for the synthesis of 3,3-disubstituted oxindoles with an all carbon quaternary center

RSC Advances ◽  
2016 ◽  
Vol 6 (78) ◽  
pp. 74683-74690 ◽  
Author(s):  
Yi-Lin Guo ◽  
Yu-Hsun Li ◽  
Hsuan-Hao Chang ◽  
Ting-Shen Kuo ◽  
Jeng-Liang Han
Keyword(s):  
Michael Addition ◽  
Molecular Sieve ◽  
Addition Reaction ◽  
Knoevenagel Condensation ◽  
Michael Addition Reaction ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Quaternary Center ◽  
Broad Scope

A mild, catalyst-free and efficient molecular sieve mediated sequential Knoevenagel condensation/decarboxylative Michael additon reaction has been developed. A broad scope of 3,3-disubstituted oxindoles were synthesized in good to excellent yields.

Zinc complexes supported by pyridine-N-oxide ligands: synthesis, structures and catalytic Michael addition reactions

2020 ◽  
Vol 49 (35) ◽  
pp. 12365-12371
Author(s):  
Xiu-Fang Mo ◽  
Chang-Feng Xiong ◽  
Ze-Wen Chen ◽  
Chao Liu ◽  
Piao He ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Michael Addition ◽  
Addition Reaction ◽  
Zinc Complexes ◽  
Addition Reactions ◽  
Michael Addition Reaction ◽  
Highly Efficient

Zinc complexes supported by pyridine-N-oxide ligands show highly efficient catalysis for Michael addition reaction. The NMR and MS experiments analysis displays intermediate [Zn(SR)2(HSR)4] has real catalytic activity for the addition reactions.

scholarly journals Asymmetric Michael addition reactions of pyrrolones with chalcones catalyzed by vicinal primary-diamine salts

RSC Advances ◽  
2017 ◽  
Vol 7 (39) ◽  
pp. 24547-24550 ◽  
Author(s):  
Xiaolei Du ◽  
Dawei Yin ◽  
Zemei Ge ◽  
Xin Wang ◽  
Runtao Li
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Addition Reactions ◽  
Michael Addition Reaction ◽  
Asymmetric Michael Addition

The asymmetric Michael addition reaction of pyrrolones with chalcones catalyzed by vicinal primary-diamine salts has been developed in good yields and high enantioselectivities.

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