scholarly journals A modular design for minor groove binding and recognition of mixed base pair sequences of DNA

2017 ◽  
Vol 53 (75) ◽  
pp. 10406-10409 ◽  
Author(s):  
Pu Guo ◽  
Ananya Paul ◽  
Arvind Kumar ◽  
Narinder K. Harika ◽  
Siming Wang ◽  
...  
Keyword(s):  
Base Pair ◽  
Modular Design ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove ◽  
Mixed Sequence ◽  
Full Turn

Mixed-sequence-binding, rationally-designed heterocyclic dications specifically recognize a full turn of the DNA minor groove.

Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles)

1993 ◽  
Vol 36 (12) ◽  
pp. 1746-1753 ◽  
Author(s):  
Terri A. Fairley ◽  
Richard R. Tidwell ◽  
Isaac Donkor ◽  
Noreen A. Naiman ◽  
Kwasi A. Ohemeng ◽  
...  
Keyword(s):  
Base Pair ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove

scholarly journals Design of DNA Minor Groove Binding Diamidines That Recognize GC Base Pair Sequences:  A Dimeric-Hinge Interaction Motif

2007 ◽  
Vol 129 (44) ◽  
pp. 13732-13743 ◽  
Author(s):  
Manoj Munde ◽  
Mohamed A. Ismail ◽  
Reem Arafa ◽  
Paul Peixoto ◽  
Catharine J. Collar ◽  
...  
Keyword(s):  
Base Pair ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove

Influence of GC and AT Specific DNA Minor Groove Binding Drugs on Intermolecular Triplex Formation in the Human c-Ki-ras Promoter†

Biochemistry ◽  
1996 ◽  
Vol 35 (4) ◽  
pp. 1106-1114 ◽  
Author(s):  
Nadarajah Vigneswaran ◽  
Charles A. Mayfield ◽  
Brad Rodu ◽  
Roger James ◽  
H.-G. Kim ◽  
...  
Keyword(s):  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove ◽  
Triplex Formation

scholarly journals DNA Minor Groove Binding with Bisbenzamidine-Ru(II) Complexes

2019 ◽  
Author(s):  
Mateo I. Sánchez ◽  
Gustavo Rama ◽  
Renata Calo ◽  
Kübra Ucar ◽  
Per Lincoln ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Coordination Compounds ◽  
Photophysical Properties ◽  
Organic Ligand ◽  
Minor Groove ◽  
The Other ◽  
Minor Groove Binding ◽  
Binding Agent ◽  
Groove Binding ◽  
Dna Minor Groove

We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis‑benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ‑[Ru(bpy)<sub>2</sub><b>b4bpy</b>]<sup>2+</sup>, <b>Δ‑4Ru</b>) shows a considerably higher DNA affinity than the parent organic ligand and than the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.

DNA Minor Groove Binding by Diamidine:Water Molecule in Ligand Recognition

2008 ◽  
Vol 24 (10) ◽  
pp. 1917-1921
Author(s):  
MA Guo-Zheng ◽  
◽  
◽  
QIU Ya-Fang ◽  
NAN Jun-Min ◽  
...  
Keyword(s):  
Minor Groove ◽  
Ligand Recognition ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove

Doxorubicin and DNA minor groove-binding oligopeptide conjugates as anticancer agents

Gene ◽  
1994 ◽  
Vol 149 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Wang Yuqiang ◽  
Huang Liren ◽  
Susan C. Wright ◽  
James W. Larrick
Keyword(s):  
Anticancer Agents ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove

scholarly journals Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide

Nanoscale ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 5550-5558 ◽  
Author(s):  
R. Mizuta ◽  
J. M. Devos ◽  
J. Webster ◽  
W. L. Ling ◽  
T. Narayanan ◽  
...  
Keyword(s):  
Self Assembly ◽  
Alkali Halide ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove ◽  
Self Assembling ◽  
System P

We describe the preparation of a novel self-assembling supramolecular nanotube system.

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