Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles

2018 ◽  
Vol 5 (19) ◽  
pp. 2805-2809 ◽  
Author(s):  
Chang-Bin Yu ◽  
Jie Wang ◽  
Yong-Gui Zhou
Keyword(s):  
Asymmetric Hydrogenation ◽  
Hydrogenation Process ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Facile Synthesis ◽  
One Pot ◽  
Brönsted Acid ◽  
Palladium Catalyzed ◽  
Intramolecular Condensation

A concise synthesis of chiral indolines has been developed through intramolecular condensation, deprotection and palladium-catalyzed asymmetric hydrogenation in a one-pot process with up to 96% ee. A strong Brønsted acid played an important role in both the formation of indoles and asymmetric hydrogenation process.

Aminoxylation of Thioalkynes through Radical-Polar Crossover

Synlett ◽  
2019 ◽  
Vol 31 (06) ◽  
pp. 592-594
Author(s):  
Giovanni Di Mauro ◽  
Martina Drescher ◽  
Sara Tkaczyk ◽  
Nuno Maulide
Keyword(s):  
Bronsted Acid ◽  
Brønsted Acid ◽  
Reaction Conditions ◽  
One Pot ◽  
Brönsted Acid ◽  
Direct Formation

A one-pot procedure for the aminoxylation of thioalkynes for the direct formation of α-functionalized thioesters under mild reaction conditions is reported. A ketenethionium ion is the key intermediate, which is generated in situ by Brønsted acid mediated protonation and undergoes a radical-polar crossover.

scholarly journals Transition metal/Brønsted acid cooperative catalysis enabled facile synthesis of 8-hydroxyquinolines through one-pot reactions of ortho-aminophenol, aldehydes and alkynes

RSC Advances ◽  
2018 ◽  
Vol 8 (59) ◽  
pp. 33968-33971 ◽  
Author(s):  
Shuyan Yu ◽  
Jingxin Wu ◽  
Hongbing Lan ◽  
Hanwen Xu ◽  
Xiaofei Shi ◽  
...  
Keyword(s):  
Transition Metal ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
One Pot ◽  
Cooperative Catalysis ◽  
Brönsted Acid

An efficient and cooperative catalytic one-pot synthetic methodology for 8-hydroxyquinoline compounds has been developed.

Palladium-Catalyzed Asymmetric Hydrogenation ofN-Hydroxy-α-imino Phosphonates Using Brønsted Acid as Activator: The First Catalytic Enantioselective Approach to ChiralN-Hydroxy-α-amino Phosphonates

2012 ◽  
Vol 354 (14-15) ◽  
pp. 2727-2733 ◽  
Author(s):  
Nataliya S. Goulioukina ◽  
Ilya A. Shergold ◽  
Grigorii N. Bondarenko ◽  
Mikhail M. Ilyin ◽  
Vadim A. Davankov ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Brönsted Acid ◽  
Palladium Catalyzed ◽  
Amino Phosphonates

scholarly journals Brønsted acid-catalyzed metal-free one-pot synthesis of benzimidazoles via [4+1] heteroannulation of ortho-phenylenediamines with β-oxodithioesters

ARKIVOC ◽  
2017 ◽  
Vol 2018 (2) ◽  
pp. 81-89
Author(s):  
Abhijeet Srivastava ◽  
Gaurav Shukla ◽  
Dhananjay Yadav ◽  
Maya Shankar Singh
Keyword(s):  
Bronsted Acid ◽  
Brønsted Acid ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Brönsted Acid ◽  
Acid Catalyzed

Brønsted Acid-catalyzed Dynamic Kinetic Resolution of in situ Formed Acyclic N,O-hemiaminals: Cascade Synthesis of Chiral Cyclic N,O-aminals

2021 ◽  
Author(s):  
Xue-Jiao Lv ◽  
Yong-Chao Ming ◽  
Hui-Chun Wu ◽  
Yankai Liu
Keyword(s):  
Kinetic Resolution ◽  
Michael Reaction ◽  
Amide Group ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Dynamic Kinetic Resolution ◽  
Brönsted Acid ◽  
Acid Catalyzed

A Brønsted acid-catalyzed cascade acyclic N,O-hemiaminal formation/oxa-Michael reaction is developed for the synthesis of cis-2,6-disubstituted tetrahydropyrans bearing an exo amide group, that is, cyclic N,O-aminals. By using TsOH, various different...

Sign in / Sign up

Export Citation Format

Share Document