Stereocontrolled construction of six vicinal stereogenic centers on a hexahydroxanthone framework through a formal [2+1+3] annulation

2019 ◽  
Vol 55 (93) ◽  
pp. 14003-14006 ◽  
Author(s):  
Shun-Qin Chang ◽  
Xiong Zou ◽  
Yi Gong ◽  
Xue-Wen He ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
Stereogenic Centers

The first example of a bifunctional donor–donor 3C synthon formed in situ from an activated methine with nitromethane through a [2+1] Michael addition, further directing a one-pot organocascade Michael/Henry cycloaddition was developed.

Cu-Catalyzed one-pot synthesis of thiochromeno-quinolinone and thiochromeno-thioflavone via oxidative double hetero Michael addition using in situ generated nucleophiles

2020 ◽  
Vol 56 (62) ◽  
pp. 8826-8829
Author(s):  
Nallappan Sundaravelu ◽  
Govindasamy Sekar
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
One Pot Synthesis

A copper catalyzed three-component synthesis of π-conjugated tetracyclic thiochromeno-quinolinone and thiochromeno-thioflavone was established via oxidative double hetero Michael addition using in situ generated nucleophiles.

ChemInform Abstract: One-Pot Synthesis of 3,4-Dihydropyridin-2-one via Michael Addition of in situ-Generated Enaminones.

ChemInform ◽  
2014 ◽  
Vol 45 (8) ◽  
pp. no-no
Author(s):  
J. B. Senthil Kumar ◽  
Neeta Kumari ◽  
Pratibha Mehta Luthra
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy

2016 ◽  
Vol 12 ◽  
pp. 2240-2249 ◽  
Author(s):  
Alexei N Izmest’ev ◽  
Galina A Gazieva ◽  
Natalya V Sigay ◽  
Sergei A Serkov ◽  
Valentina A Karnoukhova ◽  
...  
Keyword(s):  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Stereogenic Centers ◽  
Isatin Derivatives

An effective and highly regio- and diastereoselective one-pot method for the synthesis of new polynuclear dispiroheterocyclic systems with five stereogenic centers (dispiro[imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-6,3′-pyrrolidine-2′,3′′-indoles]) comprising pyrrolidinyloxindole and imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine moieties has been developed. The method relies on a 1,3-dipolar cycloaddition of azomethine ylides generated in situ from isatin derivatives and sarcosine to 6-benzylideneimidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-2,7-diones.

One-Pot Synthesis of 3,4-Dihydropyridin-2-one via Michael Addition of in situ–Generated Enaminones

2013 ◽  
Vol 43 (22) ◽  
pp. 3010-3019 ◽  
Author(s):  
J. B. Senthil Kumar ◽  
Neeta Kumari ◽  
Pratibha Mehta Luthra
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
One Pot Synthesis
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