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Author(s):  
Sivaparwathi Golla ◽  
Naveenkumar Anugu ◽  
Swathi Jalagam ◽  
Hari Prasad Kokatla

A transition-metal and hydride-free reductive aldol reaction has been developed for the synthesis of biologically active 3,3´-disubstituted oxindoles from isatin-derivatives using rongalite. In this protocol, rongalite plays the dual role...


Author(s):  
Chuanliu Yin ◽  
Lianghao Li ◽  
Chuanming Yu

Direct synthesis of isocoumarin skeletons has been realized through Rh(III)-Catalyzed [3 + 3] annulation of sulfoxonium ylides and iodonium carbenes. The synthetic protocol constructed efficiently with the broad functional group...


2022 ◽  
Author(s):  
Huaxing Zhang ◽  
Qiang Guo ◽  
Hu Cheng ◽  
Chunhao Ran ◽  
Di Wu ◽  
...  

Herein, Ag(I)-promoted regioselective intramolecular radical nucleophilic addition/rearrangement of 2-aryl diazaboroles have been accomplished for the first time to construct phenazine structures. This protocol is an umpolung strategy based on classical...


Author(s):  
Attunuri Nagireddy ◽  
Dattatri ◽  
Ramesh Kotipalli ◽  
Jagadeesh Babu Nanubolu ◽  
Maddi Sridhar Reddy

2021 ◽  
pp. 1-14
Author(s):  
Chun Shing Kwok ◽  
Debbie Jackson ◽  
Sadie Bennett ◽  
Jacopo Tafuro ◽  
Adrian Large ◽  
...  

Background/Aims Chest pain is a common symptom, but its presentation and cause varies widely, making diagnosis a challenge. This study describes the authors' experience of a nurse-led rapid access chest pain clinic, and associated use of investigation and patient outcomes. Methods A retrospective service evaluation of patients referred to a nurse-led rapid access chest pain clinic was performed. Routinely-recorded data on patient demographics, symptoms, comorbidities, medications, cardiology clinic attendances and investigations were collected. In addition, admissions to accident and emergency or inpatient, death, acute myocardial infarction and percutaneous coronary intervention within 1 year were obtained. Results A total of 279 patients were included in the evaluation between January and February 2019. Chest pain was present as a symptom in 92.8% of patients, while 37.6% of patients had shortness of breath. Only 16.8% had typical angina, while 34.4% had atypical angina. The majority (93.9%) had two or fewer cardiology clinic appointments, the most common imaging investigation used was computed tomography coronary angiogram (47.3%) and 8.2% had a stress echocardiogram or invasive angiogram. Approximately one in five patients had a hospital admission within 1 year. The mortality rate within 1 year was 1.4%, but were all non-cardiac causes. Only 3.6% underwent percutaneous coronary intervention and there was only one mortality. Conclusions This service evaluation shows that a nurse-led rapid access chest pain clinic can be safe, efficient and closely adhere to National Institute for Health and Care Excellence guidelines. Many patients do not require unnecessary and potentially harmful investigations and revascularisation rates are low.


2021 ◽  
Vol 1 (7) ◽  
pp. 1354-1356
Author(s):  
Victoria Dimakos ◽  
Stephen G. Newman
Keyword(s):  

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