Pseudoguaianelactones A–C: three unusual sesquiterpenoids from Lindera glauca with anti-inflammatory activities by inhibiting the LPS-induced expression of iNOS and COX-2

2020 ◽  
Vol 56 (10) ◽  
pp. 1517-1520 ◽  
Author(s):  
Qing-feng Ruan ◽  
Shi-qin Jiang ◽  
Xiao-yun Zheng ◽  
Yu-qian Tang ◽  
Bao Yang ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Induced Expression ◽  
New Approach ◽  
Inflammatory Drug ◽  
Cox 2 ◽  
Anti Inflammatory

The pseudoguaianelactones A–C, three unusual sesquiterpenoids isolated from Lindera glauca, showed potential anti-inflammatory activities and also provide a new approach for anti-inflammatory drug discovery.

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (ETFBO), a Versatile Precursor for Trifluoromethyl-Substituted Heteroarenes – a Short Synthesis of Celebrex® (Celecoxib)

Synlett ◽  
2017 ◽  
Vol 29 (01) ◽  
pp. 121-125 ◽  
Author(s):  
Andreas Kirschning ◽  
Heiko Sommer ◽  
Max Braun ◽  
Benjamin Schröder
Keyword(s):  
Building Block ◽  
Synthetic Approach ◽  
Elimination Reaction ◽  
Stetter Reaction ◽  
Inflammatory Drug ◽  
Short Synthesis ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Key Steps

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (ETFBO) serves as a trifluoromethyl-containing building block for the preparation of trifluoromethyl-substituted thiophenes, furans, pyrrols, and piperazines. Key steps are an addition–elimination reaction to ETFBO followed by the thiazolium-catalyzed Stetter reaction. The scope of this chemistry was demonstrated in a new synthetic approach towards the COX-2 selective, nonsteroidal anti-inflammatory drug Celebrex® (celecoxib).

Efficacy and Tolerability of Meloxicam, a COX-2 Preferential Nonsteroidal Anti-Inflammatory Drug

2002 ◽  
Vol 22 (12) ◽  
pp. 799-818 ◽  
Author(s):  
M. Del Tacca ◽  
R. Colucci ◽  
M. Fornai ◽  
C. Blandizzi
Keyword(s):  
Inflammatory Drug ◽  
Cox 2 ◽  
Anti Inflammatory

Role of COX-2 in nonsteroidal anti-inflammatory drug enteropathy in rodents

2010 ◽  
Vol 45 (7-8) ◽  
pp. 822-827 ◽  
Author(s):  
Christoph Hotz-Behofsits ◽  
Robert J Simpson ◽  
Matthew Walley ◽  
Ingvar T. Bjarnason
Keyword(s):  
Inflammatory Drug ◽  
Cox 2 ◽  
Anti Inflammatory

Safety of Selective COX‐2 Inhibitors in Aspirin/Nonsteroidal Anti‐inflammatory Drug‐Intolerant Patients: Comparison of Nimesulide, Meloxicam, and Rofecoxib

2004 ◽  
Vol 41 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Sevim Bavbek ◽  
Gülfem Çelik ◽  
Faruk Özer ◽  
Dilşad Mungan ◽  
Zeynep Mısırlıgil
Keyword(s):  
Inflammatory Drug ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Cox 2 Inhibitors
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