I2/TBHP mediated diastereoselective synthesis of spiroaziridines

2020 ◽  
Vol 18 (8) ◽  
pp. 1588-1593 ◽  
Author(s):  
Kizhakkan Thiruthi Ashitha ◽  
Puthiya Purayil Vinaya ◽  
Ajay Krishna ◽  
Deepthy Cheeran Vincent ◽  
Renjitha Jalaja ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Simple Metal ◽  
Metal Free

A simple metal free protocol for the diastereoselective synthesis of spiroaziridines using easily accessible substrates is disclosed.

Regio- and diastereoselective synthesis of trans-3,4-diaryldihydrocoumarins via metal-free [4+2] annulation of ynamides with o-hydroxybenzyl alcohols

2021 ◽  
Author(s):  
Wen-Feng Luo ◽  
Long-Wu Ye ◽  
Long Li ◽  
Peng-Cheng Qian
Keyword(s):  
Diastereoselective Synthesis ◽  
Metal Free

An efficient regio- and diastereoselective method for the construction of valuable trans-3,4-diaryldihydrocoumarins via metal-free formal [4+2] annulation of ynamides with o-hydroxybenzyl alcohols has been developed.

ChemInform Abstract: A Simple Metal-Free Catalytic Sulfoxidation under Visible Light and Air.

ChemInform ◽  
2013 ◽  
Vol 44 (19) ◽  
pp. no-no
Author(s):  
Xiangyong Gu ◽  
Xiang Li ◽  
Yahong Chai ◽  
Qi Yang ◽  
Pixu Li ◽  
...  
Keyword(s):  
Visible Light ◽  
Simple Metal ◽  
Metal Free

Reactions of Methyl Ketones and (Hetero)arylcarboxamides with N,N-Dimethylacetamide Dimethyl Acetal. A Simple Metal-Free Synthesis of 2,4,6-Trisubstituted Pyridines

2015 ◽  
Vol 68 (2) ◽  
pp. 184 ◽  
Author(s):  
Benjamin Prek ◽  
Uroš Grošelj ◽  
Marta Kasunič ◽  
Silvo Zupančič ◽  
Jurij Svete ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Single Crystal ◽  
Ammonium Acetate ◽  
Dimethyl Acetal ◽  
Methyl Ketones ◽  
Closed Vessel ◽  
Simple Metal ◽  
One Pot ◽  
X Ray ◽  
Metal Free

Two metal-free syntheses of 2,4,6-trisubstituted pyridines 10a–m and 16a–j are described. N,N,6-Trimethyl-4-(substituted)pyridin-2-amines 10 were prepared from aryl or heteroaryl methyl ketones which were transformed with N,N-dimethylacetamide dimethyl acetal (DMADMA) into enaminones 4a–m, followed by treatment with ammonium acetate to give (Z)-3-amino-1-(substituted)but-2-en-1-ones 5a–m. These were treated with DMADMA under microwave irradiation in a closed vessel at 130°C, to give via intermediates 7–9 the final products 10a–m. N2,N2,N4,N4-Tetramethyl-6-(substituted) pyridine-2,4-diamines 16a–j were prepared in a one-pot synthesis from the corresponding carboxamides 11a–j by treatment with an excess of DMADMA in a closed vessel under microwave irradiation to give via intermediates 12a–j to 15a–j the final products 16a–j. X-Ray single crystal diffractometry studies of the enaminones 5c, 5g, 5i, 5j, and 5m and 2,4,6-trisubstituted pyridines 16a, 16b, 16g, 16i, and 16j were consistent with the expected structures.

De novo synthesis of benzofurans via trifluoroacetic acid catalyzed cyclization/oxidative aromatization cascade reaction of 2-hydroxy-1,4-diones

2019 ◽  
Vol 17 (32) ◽  
pp. 7547-7551 ◽  
Author(s):  
Qiang Sha ◽  
Haixuan Liu
Keyword(s):  
Trifluoroacetic Acid ◽  
De Novo ◽  
Cascade Reaction ◽  
De Novo Synthesis ◽  
Simple Metal ◽  
Metal Free ◽  
Aromatization Reaction ◽  
Oxidative Aromatization ◽  
Acid Catalyzed

A simple metal-free cyclization/oxidative aromatization reaction starting from 2-hydroxy-1,4-diones for the de novo synthesis of benzofurans was developed.

ChemInform Abstract: Metal-Free Diastereoselective Synthesis of Diaza-bicyclo[3.2.0]heptan-7-one and Its Transformation to Functionalized Proline Esters.

ChemInform ◽  
2014 ◽  
Vol 45 (41) ◽  
pp. no-no
Author(s):  
Yogesh Kumar ◽  
Bilash Kuila ◽  
Dinesh Mahajan ◽  
Prabhpreet Singh ◽  
Balaram Mohapatra ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Metal Free

Radical Metal-Free Borylation of Aryl Iodides

Synthesis ◽  
2017 ◽  
Vol 49 (21) ◽  
pp. 4759-4768 ◽  
Author(s):  
Sandra Pinet ◽  
Mathieu Pucheault ◽  
Virginie Liautard ◽  
Mégane Debiais
Keyword(s):  
Steric Hindrance ◽  
Radical Mechanism ◽  
Electronic Effects ◽  
Simple Metal ◽  
Reaction Conditions ◽  
Metal Free ◽  
Aryl Iodides ◽  
Reaction Proceeds ◽  
Electronic Effects Of Substituents

A simple metal-free borylation of aryl iodides mediated by a fluoride sp2–sp3 diboron adduct is described. The reaction conditions are compatible with various functional groups. Electronic effects of substituents do not affect the borylation while steric hindrance does. The reaction proceeds via a radical mechanism in which pyridine serves to stabilize the boryl radicals, generated in situ.

I2–DMSO–PTSA: a simple and metal free oxidative cross coupling of imidazo[1,2-a]pyridines and methylketones

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19418-19425 ◽  
Author(s):  
Madhu Chennapuram ◽  
Narender Reddy Emmadi ◽  
Chiranjeevi Bingi ◽  
Krishnaiah Atmakur
Keyword(s):  
Cross Coupling ◽  
Methyl Ketones ◽  
Simple Metal ◽  
One Pot ◽  
Metal Free

A simple, metal free and selective oxidative cross-coupling promoted by I2–DMSO in presence of PTSA has been developed with the use of imidazo[1,2-a]pyridines (1) and methyl ketones (2) to access 3 in a one pot reaction.

Visible light photocatalysis with CBr4: a highly selective aerobic photooxidation of methylarenes to aldehydes

RSC Advances ◽  
2016 ◽  
Vol 6 (18) ◽  
pp. 14547-14551 ◽  
Author(s):  
Shubhangi Tripathi ◽  
Sachchida N. Singh ◽  
Lal Dhar S. Yadav
Keyword(s):  
Visible Light ◽  
Molecular Oxygen ◽  
Selective Oxidation ◽  
Aromatic Aldehydes ◽  
Visible Light Photocatalysis ◽  
Simple Metal ◽  
Metal Free

An efficient, operationally simple, metal-free strategy for the selective oxidation of methylarenes to aromatic aldehydes through visible light photocatalysis employing CBr4 and molecular oxygen is reported.

Metal-free diastereoselective synthesis of diaza-bicyclo[3.2.0]heptan-7-one and its transformation to functionalized proline esters

2014 ◽  
Vol 55 (17) ◽  
pp. 2793-2795 ◽  
Author(s):  
Yogesh Kumar ◽  
Bilash Kuila ◽  
Dinesh Mahajan ◽  
Prabhpreet Singh ◽  
Balaram Mohapatra ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Metal Free
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