Red-blood-cell-membrane-enveloped magnetic nanoclusters as a biomimetic theranostic nanoplatform for bimodal imaging-guided cancer photothermal therapy

2020 ◽  
Vol 8 (4) ◽  
pp. 803-812 ◽  
Author(s):  
Sheng Wang ◽  
Yipengchen Yin ◽  
Wang Song ◽  
Qin Zhang ◽  
Zhijuan Yang ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Photothermal Therapy ◽  
Magnetic Nanoclusters ◽  
Red Blood Cell Membrane ◽  
Bimodal Imaging ◽  
Tumor Homing

Biomimetic Cyp-MNC@RBCs with high tumor homing capacity are utilized as promising nanotheranostics, enabling bimodal imaging-guided cancer photothermal therapy.

Red blood cell membrane camouflaged magnetic nanoclusters for imaging-guided photothermal therapy

Biomaterials ◽  
2016 ◽  
Vol 92 ◽  
pp. 13-24 ◽  
Author(s):  
Xiaoqing Ren ◽  
Rui Zheng ◽  
Xiaoling Fang ◽  
Xiaofei Wang ◽  
Xiaoyan Zhang ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Photothermal Therapy ◽  
Magnetic Nanoclusters ◽  
Red Blood Cell Membrane

scholarly journals Stealth Polydopamine-Based Nanoparticles with Red Blood Cell Membrane for the Chemo-Photothermal Therapy of Cancer

2020 ◽  
Vol 3 (4) ◽  
pp. 2350-2359
Author(s):  
Haijun Wang ◽  
Gareth R. Williams ◽  
Xiaotian Xie ◽  
Meng Wu ◽  
Junzi Wu ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Photothermal Therapy ◽  
Red Blood Cell Membrane

scholarly journals Red blood cell membrane-camouflaged melanin nanoparticles for enhanced photothermal therapy

Biomaterials ◽  
2017 ◽  
Vol 143 ◽  
pp. 29-45 ◽  
Author(s):  
Qin Jiang ◽  
Zimiao Luo ◽  
Yongzhi Men ◽  
Peng Yang ◽  
Haibao Peng ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Photothermal Therapy ◽  
Red Blood Cell Membrane ◽  
Melanin Nanoparticles

scholarly journals Red Blood Cell Membrane-Camouflaged Tedizolid Phosphate-Loaded PLGA Nanoparticles for Bacterial-Infection Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 99
Author(s):  
Xinyi Wu ◽  
Yichen Li ◽  
Faisal Raza ◽  
Xuerui Wang ◽  
Shulei Zhang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cell Membrane ◽  
Blood Cell ◽  
Sustained Release ◽  
Delivery System ◽  
Red Blood Cell ◽  
Multiple Drug Resistance ◽  
Plga Nanoparticles ◽  
Multiple Drug ◽  
Red Blood Cell Membrane

Multiple drug resistance (MDR) in bacterial infections is developed with the abuse of antibiotics, posing a severe threat to global health. Tedizolid phosphate (TR-701) is an efficient prodrug of tedizolid (TR-700) against gram-positive bacteria, including methicillin-sensitive staphylococcus aureus (MSSA) and methicillin-resistant staphylococcus aureus (MRSA). Herein, a novel drug delivery system: Red blood cell membrane (RBCM) coated TR-701-loaded polylactic acid-glycolic acid copolymer (PLGA) nanoparticles (RBCM-PLGA-TR-701NPs, RPTR-701Ns) was proposed. The RPTR-701Ns possessed a double-layer core-shell structure with 192.50 ± 5.85 nm in size, an average encapsulation efficiency of 36.63% and a 48 h-sustained release in vitro. Superior bio-compatibility was confirmed with red blood cells (RBCs) and HEK 293 cells. Due to the RBCM coating, RPTR-701Ns on one hand significantly reduced phagocytosis by RAW 264.7 cells as compared to PTR-701Ns, showing an immune escape effect. On the other hand, RPTR-701Ns had an advanced exotoxins neutralization ability, which helped reduce the damage of MRSA exotoxins to RBCs by 17.13%. Furthermore, excellent in vivo bacteria elimination and promoted wound healing were observed of RPTR-701Ns with a MRSA-infected mice model without causing toxicity. In summary, the novel delivery system provides a synergistic antibacterial treatment of both sustained release and bacterial toxins absorption, facilitating the incorporation of TR-701 into modern nanotechnology.

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