Late-stage functionalization of peptides via a palladium-catalyzed C(sp3)–H activation strategy

2020 ◽  
Vol 56 (90) ◽  
pp. 13950-13958 ◽  
Author(s):  
Bei-Bei Zhan ◽  
Meng-Xue Jiang ◽  
Bing-Feng Shi
Keyword(s):  
Late Stage ◽  
Recent Advances ◽  
Palladium Catalyzed

Recent advances in the late-stage modification of peptides via palladium-catalyzed C(sp3)–H functionalization are summarized.

Sequential C-Selective Difluoromethylation/Pd-Catalyzed Decarboxylative Protonation: An Efficient Access to Tertiary Difluoromethylated Scaffolds

2019 ◽  
Author(s):  
Nicolas Duchemin ◽  
Roberto Buccafusca ◽  
Marc Daumas ◽  
Vincent Ferey ◽  
Stellios Arseniyadis
Keyword(s):  
Drug Development ◽  
Late Stage ◽  
Efficient Access ◽  
Palladium Catalyzed ◽  
General Method

We report here a general method that allows a highly straightforward access to tertiary difluoromethylated compounds. The strategy relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and an unprecedented palladium-catalyzed decarboxylative protonation. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.<br>

scholarly journals Palladium-Catalyzed Late-Stage Direct Arene Cyanation

Chem ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. 97-107 ◽  
Author(s):  
Da Zhao ◽  
Peng Xu ◽  
Tobias Ritter
Keyword(s):  
Late Stage ◽  
Palladium Catalyzed

scholarly journals Cover Feature: Recent Advances in Palladium-Catalyzed Carboxylation with CO2 (Eur. J. Org. Chem. 6/2018)

2018 ◽  
Vol 2018 (6) ◽  
pp. 695-695
Author(s):  
Jian Song ◽  
Qing Liu ◽  
Hui Liu ◽  
Xuefeng Jiang
Keyword(s):  
Recent Advances ◽  
Palladium Catalyzed

Recent advances in palladium-catalyzed (hetero)annulation of C=C bonds with ambiphilic organo(pseudo)halides

2021 ◽  
Author(s):  
Hui-Qi Ni ◽  
Phillippa Cooper ◽  
Keary M. Engle
Keyword(s):  
Recent Advances ◽  
Palladium Catalyzed ◽  
Pseudo Halides

Palladium has proven to be effective in catalyzing the (hetero)annulation of C=C bonds with ambiphilic organo(pseudo)halides. Through the employment of appropriate ambiphilic coupling partners, efficient annulation of a variety of...

Recent advances in palladium-catalyzed C(sp3)/C(sp2)-H bond functionalizations: Access to C-branched glycosides

2021 ◽  
Author(s):  
Pintu Kumar Mandal ◽  
Zanjila Azeem
Keyword(s):  
Recent Advances ◽  
Palladium Catalyzed ◽  
Directing Group

Over the recent decades, tremendous interest has been developed involving the transformation of complex substrates by the C–H activation and functionalization. In particular, the palladium-catalyzed directing and non-directing group-assisted C-H...

scholarly journals Biocatalytic Alkylation Cascades: Recent Advances and Future Opportunities for Late‐Stage Functionalization

ChemBioChem ◽  
2020 ◽  
Vol 21 (20) ◽  
pp. 2890-2897 ◽  
Author(s):  
Iain J. W. McKean ◽  
Paul A. Hoskisson ◽  
Glenn A. Burley
Keyword(s):  
Late Stage ◽  
Recent Advances
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