scholarly journals Second derivative synchronous fluorescence determination of avanafil in the presence of its acid-induced degradation product aided by powerful Lean Six Sigma tools augmented with D-optimal design

RSC Advances ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 3834-3842
Author(s):  
Khalid A. M. Attia ◽  
Ahmad A. Mohamad ◽  
Mohamed S. Emara ◽  
Ahmed M. Abdel-Raoof ◽  
Mohamed A. Hasan ◽  
...  
Keyword(s):  
Optimal Design ◽  
Quantitative Determination ◽  
Degradation Product ◽  
Six Sigma ◽  
Lean Six Sigma ◽  
Synchronous Fluorescence ◽  
Second Derivative ◽  
Fluorescence Determination ◽  
Spectrofluorimetric Method

In this work, the quantitative determination of an erectile dysfunctional drug avanafil in the presence of its acid-induced degradation product was achieved via the application of a pre-optimized novel spectrofluorimetric method.

Determination of linagliptin and empagliflozin by UPLC and HPTLC techniques aided by Lean Six Sigma approach

2021 ◽  
Author(s):  
Ebrahim A. El‐Desouky ◽  
Ahmed M. Abdel‐Raoof ◽  
Ashraf Abdel‐Fattah ◽  
Ahmed Abdel‐Zaher ◽  
Ayman O. E. Osman ◽  
...  
Keyword(s):  
Six Sigma ◽  
Lean Six Sigma ◽  
Six Sigma Approach

Simultaneous determination of amlodipine and metoprolol in their combined dosage form using a synchronous fluorescence spectrofluorimetric method

Luminescence ◽  
2017 ◽  
Vol 33 (2) ◽  
pp. 364-369 ◽  
Author(s):  
Mokhtar M. Mabrouk ◽  
Sherin F. Hammad ◽  
Samah F. El-Malla ◽  
Eman A. Elshenawy
Keyword(s):  
Simultaneous Determination ◽  
Dosage Form ◽  
Synchronous Fluorescence ◽  
Spectrofluorimetric Method

Chromatographic Study of Azintamide in Bulk Powder and in Pharmaceutical Formulation in the Presence of Its Degradation Form

2017 ◽  
Vol 100 (2) ◽  
pp. 422-428 ◽  
Author(s):  
Maha A Hegazy ◽  
Waleed A Hassanain ◽  
Laila E Abdel Fattah ◽  
Hamed M El-Fatatry
Keyword(s):  
Quantitative Determination ◽  
Degradation Product ◽  
Internal Standard ◽  
Reversed Phase ◽  
Pharmaceutical Formulation ◽  
Chromatographic Study ◽  
Significant Difference ◽  
Tlc Plates ◽  
Acidic Degradation

Abstract Two specific, sensitive, and precise stability-indicating chromatographic methods were developed, optimized, and validated for the determination of Azintamide (AZ) in the presence of its degradation product. The first method was TLC combined with the densitometric determination of the separated bands. Separation was achieved using silica gel 60 F254 TLC plates and chloroform–acetone–glacial acetic acid (7.5 + 2.1 + 0.4, v/v/v) as the developing system. Good correlations were obtained between the integrated peak area of the studied drug and its corresponding concentrations in the linearity range. The second method used HPLC with UV diode-array detection, in which the proposed method was applied for the quantitative determination of AZ in the presence of its acidic degradation product and the quantitative determination of the acid-induced degradation product of AZ (AZ Deg) using pentoxifylline as the internal standard. The proposed components were separated on a reversed-phase C18 analytical column using acetonitrile–water (50 + 50, v/v). The flow rate was maintained at 0.55 mL/min and the detection wavelength was 260 nm. Linear regressions were obtained in the range of 1–30 and 0.3–16 μg/mL for AZ and AZ Deg, respectively. Different parameters affecting the suggested methods were optimized for maximum separation of the cited components. The suggested methods were validated in compliance with the International Conference on Harmonization guidelines and successfully applied for the determination of AZ in its pure powder form and in its pharmaceutical formulation. Both methods were also statistically compared with the reported method with no significant difference in performance observed.

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