Rh(iii)-Catalyzed C–H allylation/annulative Markovnikov addition with 5-methylene-1,3-dioxan-2-one: formation of isoquinolinones containing a C3 quaternary centre

Author(s):  
Yuanfei Zhang ◽  
Xinghua Li ◽  
Jintong Bai ◽  
Zhaoyu Huang ◽  
Minhai Yin ◽  
...  

Rh(iii)-Catalyzed C–H allylation/annulative Markovnikov addition reaction was disclosed, offering isoquinolinones containing a C3 quaternary centre. By using this method as the key step, the US28 inverse agonist analogs were synthesized.

ChemInform ◽  
2010 ◽  
Vol 41 (48) ◽  
pp. no-no
Author(s):  
Azim Ziyaei Halimehjani ◽  
Katayoun Marjani ◽  
Akram Ashouri

Author(s):  
Azim Ziyaei Halimehjani ◽  
Arefeh Dadras ◽  
Meraj Ramezani ◽  
Elham V. Shamiri ◽  
Seyyed E. Hooshmand ◽  
...  

Synlett ◽  
2018 ◽  
Vol 29 (17) ◽  
pp. 2218-2224 ◽  
Author(s):  
Jeffrey Bandar ◽  
Chaosheng Luo

The direct anti-Markovnikov addition of alcohols to styrene derivatives represents a streamlined route to β-phenethyl ethers, a substructure frequently found in pharmaceuticals and other bioactive ­molecules. Here, we discuss how the development of such a reaction can complement and address limitations of current methods for β-phenethyl ether synthesis. In particular, we highlight our recent ­approach toward achieving this challenging alcohol addition reaction through P4-t-Bu superbase catalysis. A summary of compatible aryl alkenes and alcohols is provided to inform readers of potential applications of this new catalytic transformation, as well as its current limitations and future directions.1 Introduction2 Anti-Markovnikov Alcohol Addition to Aryl Alkenes: Background3 Superbase-Catalyzed Alcohol Addition to Aryl Alkenes4 Summary and Outlook


2007 ◽  
Vol 48 (27) ◽  
pp. 4669-4673 ◽  
Author(s):  
Naotomo Dobashi ◽  
Kouichiro Fuse ◽  
Takako Hoshino ◽  
Jun Kanada ◽  
Taigo Kashiwabara ◽  
...  

Synthesis ◽  
2013 ◽  
Vol 45 (11) ◽  
pp. 1483-1488 ◽  
Author(s):  
Azim Ziyaei Halimehjani ◽  
Hamed Pasha Zanussi ◽  
Mohammad Ranjbari

ChemInform ◽  
2013 ◽  
Vol 44 (38) ◽  
pp. no-no
Author(s):  
Azim Ziyaei Halimehjani ◽  
Hamed Pasha Zanussi ◽  
Mohammad Amin Ranjbari

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