scholarly journals Copper-catalyzed asymmetric cyclization of alkenyl diynes: method development and new mechanistic insights

2021 ◽  
Author(s):  
Xin-Qi Zhu ◽  
Pan Hong ◽  
Yan-Xin Zheng ◽  
Ying-Ying Zhen ◽  
Feng-Lin Hong ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Method Development ◽  
Asymmetric Reactions ◽  
Metal Carbenes ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Reactions

Metal carbenes have proven to be one of the most important and useful intermediates in organic synthesis, but catalytic asymmetric reactions involving metal carbenes are still scarce and remain a...

scholarly journals Pyrazoleamides in Catalytic Asymmetric Reactions: Recent Advances

2021 ◽  
Author(s):  
Sara Meninno ◽  
Francesca Franco ◽  
Maurizio Benaglia ◽  
Alessandra Lattanzi
Keyword(s):  
Asymmetric Reactions ◽  
Recent Advances ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Reactions

A Facile Synthesis of the Enantiopure, Nitrogen-Substituted 2,2'-Diamino-1,1'-binaphthyls as Potential Ligands for Catalytic Asymmetric Reactions

1998 ◽  
Vol 63 (4) ◽  
pp. 515-519 ◽  
Author(s):  
Štěpán Vyskočil ◽  
Martin Smrčina ◽  
Pavel Kočovský
Keyword(s):  
Room Temperature ◽  
Asymmetric Reactions ◽  
Reductive Alkylation ◽  
Facile Synthesis ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Reactions

Reductive alkylation of (R)-(+)-2,2'-diamino-1,1'-binaphthyl (1) with various ketones has been accomplished by means of NaBH4/H2SO4 in THF at room temperature. Bisalkylation predominated with the sterically less demanding acetone (1→3a; 82%), whereas the bulky 2-adamantanone afforded mainly the monoalkylated product 4c (71%). Both mono- and bisalkylated diamines (R)-3 and (R)-4 were reductively permethylated on reaction with CH2O, NaBH4, and H2SO4. The Pd(0)-catalyzed phenylation of (R)-(+)-1 with PhBr afforded the N,N'-diphenyl derivative (R)-7 (70%).

Sign in / Sign up

Export Citation Format

Share Document