Reductive alkylation of nitriles with aldehydes and ketones using nickel nanoparticles supported on NaX zeolite as catalyst proceeds at 140-200 °C with the formation of the corresponding secondary and tertiary amines in 46-80 % yields.
The synthesis of medicinally relevant α-difluoroalkylated amines by an iridium-catalyzed reductive alkylation of tertiary amides and lactams with difluoro-Reformatsky reagents, is described. This report features the introduction of various geminal difluoro-acetates and -acetamides as well as late stage derivatization of APIs, gram scale synthesis and downstream functionalizations.
REDUCTIVE ALKYLATION OF NITRILES WITH CARBONYL COMPOUNDS IN THE PRESENCE OF NANOSTUCTURED SUPPORTED NICKEL CATALYST
