Kinetic isotope effect in hydrogen isotope exchange between diphenylphosphine and methanol or 2-methylpropane-2-thiol in aprotic solvents

1990 ◽  
pp. 2045 ◽  
Author(s):  
Andrzej Wawer ◽  
Iwona Wawer
Keyword(s):  
Isotope Effect ◽  
Hydrogen Isotope ◽  
Isotope Exchange ◽  
Kinetic Isotope Effect ◽  
Aprotic Solvents ◽  
Hydrogen Isotope Exchange ◽  
Kinetic Isotope

Fundamental studies on kinetic isotope effect (KIE) of hydrogen isotope fractionation in natural gas systems

2011 ◽  
Vol 75 (10) ◽  
pp. 2696-2707 ◽  
Author(s):  
Yunyan Ni ◽  
Qisheng Ma ◽  
Geoffrey S. Ellis ◽  
Jinxing Dai ◽  
Barry Katz ◽  
...  
Keyword(s):  
Natural Gas ◽  
Isotope Effect ◽  
Hydrogen Isotope ◽  
Isotope Fractionation ◽  
Kinetic Isotope Effect ◽  
Kinetic Isotope

The Determination of the Preferred Stereochemistry and the Magnitude of the Hydrogen Isotope Effect for 1,3 Elimination in the Locked Norbornyl System Methyl exo-2-Bromo-1-norbornanecarboxylate-endo, endo-5,6-d2

1975 ◽  
Vol 53 (1) ◽  
pp. 26-40 ◽  
Author(s):  
Nick Henry Werstiuk
Keyword(s):  
Isotope Effect ◽  
Hydrogen Isotope ◽  
Kinetic Isotope Effect ◽  
Front Face ◽  
Elimination Kinetic ◽  
Kinetic Isotope ◽  
Hydrogen Isotope Effect

Methyl exo-2-bromo-1-norobornanecarboxylate-endo,endo-5,6-d2 (1b) has been prepared and solvolyzed at 112° in 80:20 EtOH-H2O buffered with NaOAc. The loss of 85–90% of the deuterium available on the front face of 1b in the formation of the tricyclic ester 6D coupled with a novel analysis established that the endo:exo preference for 1,3 elimination is at least 15:1 to 20:1. A comparison of the solvolytic kinetic isotope effect (1.18 ± 0.04) for 1b and the 1,3-elimination kinetic isotope effect (1.45–1.6) with data for 1,2 eliminations indicates that elimination occurs from the classical, perhaps 1,3 hyperconjugatively stabilized carbocation 20. The endo:exo preference established in this study is used to reinterpret 1,3-elimination data determined by Collins in the solvolysis of deuteriohydroxyphenyl norbornyl tosylates.

A Kinetic Isotope Effect and Isotope Exchange Study of the Nonenzymatic and the Equine Serum Butyrylcholinesterase-Catalyzed Thioester Hydrolysis

2013 ◽  
Vol 78 (23) ◽  
pp. 12029-12039 ◽  
Author(s):  
Lori I. Robins ◽  
Kristen M. Meisenheimer ◽  
Emily J. Fogle ◽  
Cory A. Chaplan ◽  
Richard L. Redman ◽  
...  
Keyword(s):  
Isotope Effect ◽  
Isotope Exchange ◽  
Kinetic Isotope Effect ◽  
Kinetic Isotope ◽  
Exchange Study
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