Immunogenicity of DNA modified by singlet oxygen: implications in systemic lupus erythematosus and cancer

2007 ◽  
Vol 46 (2) ◽  
pp. 97 ◽  
Author(s):  
Farina Khan ◽  
Fozia Khan ◽  
Rashid Ali
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Singlet Oxygen ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Immunogenicity of singlet oxygen modified human DNA: Implications for anti-DNA antibodies in systemic lupus erythematosus

2007 ◽  
Vol 124 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Abdurahman Saud Al Arfaj ◽  
Abdul Rauf Chowdhary ◽  
Najma Khalil ◽  
Rashid Ali
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Singlet Oxygen ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Human Dna ◽  
Dna Antibodies

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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