scholarly journals Enhancement of the anti-anabolic response to adenosine 3′:5′-cyclic monophosphate during development. The inhibition of hepatic protein synthesis

1977 ◽  
Vol 168 (2) ◽  
pp. 271-275 ◽  
Author(s):  
A Klaipongpan ◽  
D P Bloxham ◽  
M Akhtar
Keyword(s):  
Protein Synthesis ◽  
Cyclic Amp ◽  
Rat Liver ◽  
Anabolic Response ◽  
Cyclic Monophosphate ◽  
Age Dependent ◽  
Inhibition Of Protein Synthesis ◽  
Dependent Inhibition ◽  
Hepatic Protein Synthesis

Cyclic AMP causes an age-dependent inhibition of protein synthesis in rat liver. The onset of inhibition is about 10—12 days after birth. The developmental response to cyclic AMP is associated with a change in the microsomal component of the protein-synthesizing system.

scholarly journals Anti-anabolic effects of adenosine 3′:5′-cyclic monophosphate. Inhibition of protein synthesis

1974 ◽  
Vol 138 (3) ◽  
pp. 335-340 ◽  
Author(s):  
Anthony Sellers ◽  
David P. Bloxham ◽  
Kenneth A. Munday ◽  
Muhammad Akhtar
Keyword(s):  
Protein Synthesis ◽  
Cyclic Amp ◽  
Rat Liver ◽  
Physiological Role ◽  
Free System ◽  
Cell Free System ◽  
Cyclic Monophosphate ◽  
Anabolic Action ◽  
Inhibition Of Protein Synthesis ◽  
A Cell

1. Evidence is presented that cyclic AMP inhibits the incorporation of l-[4,5-3H]leucine into protein in a cell-free system from rat liver. This inhibition occurs after aminoacyl-tRNA formation. 2. Microsomal fractions, isolated after the incubation of postmitochondrial supernatant with cyclic AMP and ATP, show a diminished ability to synthesize protein. Both cyclic AMP and ATP are required for this effect. 3. A possible physiological role for the anti-anabolic action of cyclic AMP is discussed in terms of the control of gluconeogenesis.

scholarly journals Effects of the hepatotoxic agents retrorsine and aflatoxin B1 on hepatic protein synthesis in the rat

1968 ◽  
Vol 109 (1) ◽  
pp. 87-91 ◽  
Author(s):  
S. Villa-Treviño ◽  
D. D. Leaver
Keyword(s):  
Amino Acids ◽  
Protein Synthesis ◽  
Rat Liver ◽  
Aflatoxin B1 ◽  
Plasma Proteins ◽  
Pyrrolizidine Alkaloid ◽  
Main Site ◽  
Nuclear Rna ◽  
Hepatic Protein Synthesis

1. Aflatoxin and the pyrrolizidine alkaloid retrorsine inhibited the incorporation of labelled amino acids into rat liver and plasma proteins in vivo. Inhibition was greater and detected earlier with retrorsine (1hr.) than with aflatoxin (3hr.). 2. Both toxins affected the liver ribosomal aggregates, causing increases in the proportion of monomers plus dimers. The effect of retrorsine was greater than that of aflatoxin. 3. Incorporation of labelled amino acids into proteins of cell-free preparations of liver from rats treated with aflatoxin was lower than in control preparations. The main site of inhibition appeared to be the ribosomes. 4. Both toxins inhibited the incorporation of orotate into liver nuclear RNA 1hr. after administration.

Activated ribosomal RNA synthesis in regenerated rat liver upon inhibition of protein synthesis

1991 ◽  
Vol 15 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Emil H. Nikolov ◽  
Bistra B. Nankova ◽  
Mariana D. Dabeva
Keyword(s):  
Protein Synthesis ◽  
Rat Liver ◽  
Ribosomal Rna ◽  
Rna Synthesis ◽  
Inhibition Of Protein Synthesis

Inhibition of protein synthesis: A basis for tunicamycin-induced decrease in rat liver cytochrome P-450

Life Sciences ◽  
1985 ◽  
Vol 37 (15) ◽  
pp. 1411-1417 ◽  
Author(s):  
Yogendra Singh ◽  
Vilas Shirhatti ◽  
C.T. Liu ◽  
Dennis R. Feller ◽  
Gopal Krishna
Keyword(s):  
Protein Synthesis ◽  
Rat Liver ◽  
Liver Cytochrome ◽  
Inhibition Of Protein Synthesis ◽  
Cytochrome P 450
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