A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys

2014 ◽  
Vol 458 (3) ◽  
pp. 513-523 ◽  
Author(s):  
James S. Pham ◽  
Reiko Sakaguchi ◽  
Lee M. Yeoh ◽  
Nilushi S. De Silva ◽  
Geoffrey I. McFadden ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Parasite ◽  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum

The malaria parasite Plasmodium falciparum possesses a single cysteinyl-tRNA synthetase. We show that this synthetase is dual-targeted to the Plasmodium plastid and cytosol. We demonstrate that this enzyme has evolved to recognize and charge nuclear and organellar tRNA substrates.

Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum

2018 ◽  
Vol 23 (6) ◽  
pp. 1233-1240 ◽  
Author(s):  
Yogavel Manickam ◽  
Rini Chaturvedi ◽  
Palak Babbar ◽  
Nipun Malhotra ◽  
Vitul Jain ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Drug Targeting ◽  
Malaria Parasite ◽  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum

scholarly journals Interactions between Merozoite Surface Proteins 1, 6, and 7 of the Malaria Parasite Plasmodium falciparum

2006 ◽  
Vol 281 (42) ◽  
pp. 31517-31527
Author(s):  
Christian W. Kauth ◽  
Ute Woehlbier ◽  
Michaela Kern ◽  
Zeleke Mekonnen ◽  
Rolf Lutz ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Parasite ◽  
Surface Proteins ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum

The plastid DNA of the malaria parasite Plasmodium falciparum is replicated by two mechanisms

2002 ◽  
Vol 45 (2) ◽  
pp. 533-542 ◽  
Author(s):  
D. H. Williamson ◽  
P. R. Preiser ◽  
P. W. Moore ◽  
S. McCready ◽  
M. Strath ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Parasite ◽  
Plastid Dna ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum
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