Role of the pentose phosphate pathway in the provision of precursors for nucleic acid biosynthesis in bloodstream Trypanosoma brucei

1990 ◽  
Vol 18 (5) ◽  
pp. 870-871 ◽  
Author(s):  
KATINA J. CONSTANTINIDES ◽  
JANET A. PRYKE ◽  
ROBERT EISENTHAL
Keyword(s):  
Nucleic Acid ◽  
Trypanosoma Brucei ◽  
Pentose Phosphate Pathway ◽  
Pentose Phosphate ◽  
Acid Biosynthesis ◽  
Nucleic Acid Biosynthesis

Computer study of the role of hydration in the accuracy of nucleic acid biosynthesis

1999 ◽  
Vol 493 (1-3) ◽  
pp. 301-308 ◽  
Author(s):  
E. Gonzalez-Jiménez ◽  
I. Castro-Valdez ◽  
E. López-Apresa ◽  
S.V. Filippov ◽  
A.V. Teplukhin ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Computer Study ◽  
Acid Biosynthesis ◽  
Nucleic Acid Biosynthesis

scholarly journals Antitrypanosomal Activities of Fluoroquinolones with Pyrrolidinyl Substitutions

2003 ◽  
Vol 47 (9) ◽  
pp. 3015-3017 ◽  
Author(s):  
Elizabeth Nenortas ◽  
Tomasz Kulikowicz ◽  
Christian Burri ◽  
Theresa A. Shapiro
Keyword(s):  
Nucleic Acid ◽  
Trypanosoma Brucei ◽  
Mammalian Cells ◽  
Topoisomerase Ii ◽  
Acid Biosynthesis ◽  
Selective Toxicity ◽  
Dna Complexes ◽  
Antitrypanosomal Activity ◽  
Nucleic Acid Biosynthesis ◽  
Thiazolidine Ring

ABSTRACT Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid biosynthesis in trypanosomes, characteristics of topoisomerase II inhibition.

A model for the role of the proline-linked pentose phosphate pathway in polymeric dye tolerance in oregano

2001 ◽  
Vol 36 (10) ◽  
pp. 941-946 ◽  
Author(s):  
Zuoxing Zheng ◽  
Urja Sheth ◽  
Mohan Nadiga ◽  
Jennifer L. Pinkham ◽  
Kalidas Shetty
Keyword(s):  
Pentose Phosphate Pathway ◽  
Pentose Phosphate ◽  
Polymeric Dye

Significance of the Non-Oxidative Pentose Phosphate Pathway in Aspergillus oryzae Grown on Different Carbon Sources

1991 ◽  
Vol 46 (3-4) ◽  
pp. 223-227 ◽  
Author(s):  
Maria Luisa Peleato ◽  
Teresa Muiño-Blanco ◽  
José Alvaro Cebrian Pérez ◽  
Manuel José López-Pérez
Keyword(s):  
Aspergillus Oryzae ◽  
Pentose Phosphate Pathway ◽  
Enzyme Activities ◽  
Developmental Stages ◽  
Carbon Sources ◽  
Pentose Phosphate ◽  
Oxidative Pentose Phosphate Pathway ◽  
Pentose Pathway ◽  
Hexose Phosphates

Specific enzyme activities of the non-oxidative pentose phosphate pathway in Aspergillus oryzae mycelia grown on different carbon sources were determined. Mycelia grown on glucose, mannitol and ribose show the highest specific activities, ribose 5-phosphate isomerase being specially very enhanced. Moreover, transketolase, transaldolase, ribose 5-phosphate isomerase and ribulose 5-phosphate 3-epimerase were determined in different developmental stages of mycelia grown on glucose, mannitol and ribose. The non-oxidative pentose phosphate pathway is more active during conidiogenesis, except for ribulose 5-phosphate 3-epimerase, suggesting a fundamental role of this pathway during that stage to supply pentoses for nucleic acids biosynthesis. A general decrease of the enzyme activities was found in sporulated mycelia. Arabinose 5-phosphate was tested as metabolite of the pentose pathway. This pentose phosphate was not converted into hexose phosphates or triose phosphates and inhibits significantly the ribose 5-phosphate utilization, being therefore unappropriate to support the Aspergillus oryzae growth.

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