Protease-resistant PrP accumulation and scrapie agent replication: a role for sulphated glycosaminoglycans?

1994 ◽  
Vol 22 (1) ◽  
pp. 163-167 ◽  
Author(s):  
Byron Caughey
Keyword(s):  
Scrapie Agent ◽  
Sulphated Glycosaminoglycans ◽  
Agent Replication

Scrapie-associated PrP accumulation and agent replication: effects of sulphated glycosaminoglycan analogues

1994 ◽  
Vol 343 (1306) ◽  
pp. 399-404 ◽  
Keyword(s):  
Congo Red ◽  
Therapeutic Agents ◽  
Transmissible Spongiform Encephalopathies ◽  
Spongiform Encephalopathies ◽  
Scrapie Agent ◽  
Sulphated Glycosaminoglycans ◽  
Relative Potencies ◽  
Sulphated Glycosaminoglycan ◽  
Agent Replication

An abnormally protease-resistant and apparently neuropathogenic form of PrP accumulates in the brains of hosts with scrapie and related transmissible spongiform encephalopathies. Studies with scrapieinfected neuroblastom a cells have highlighted dramatic differences in the metabolism of the normal (protease-sensitive) and scrapie-associated (protease-resistant) isoforms of PrP. Furthermore, this model has been useful in identifying inhibitors of protease-resistant PrP accumulation and scrapie agent replication which are valuable as potential therapeutic agents and as probes of the mechanism of protease-resistant PrP formation. These inhibitors include the amyloid stain Congo red and certain sulphated glycans which are glycosaminoglycans themselves or glycosaminoglycan analogues. The relative potencies of various sulphated glycans correlate with their previously determ ined anti-scrapie activities in vivo , suggesting that the prophylactic effects of sulphated polyanions is due to inhibition of protease-resistant PrP accumulation. These and other observations suggest that an interaction of PrP with endogenous sulphated glycosaminoglycans or proteoglycans is important in protease-resistant PrP accumulation, and raise the possibility that therapies for transmissible spongiform encephalopathies and other amyloidoses could be based on blocking (pre)am yloid-glycosaminoglycan interactions.

scholarly journals MS-8209, a water-soluble amphotericin B derivative, affects both scrapie agent replication and PrPres accumulation in Syrian hamster scrapie.

1999 ◽  
Vol 80 (4) ◽  
pp. 1079-1085 ◽  
Author(s):  
K T Adjou ◽  
R Demaimay ◽  
J P Deslys ◽  
C I Lasm√©zas ◽  
V Beringue ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Syrian Hamster ◽  
Water Soluble ◽  
Scrapie Agent ◽  
Agent Replication

scholarly journals Congo red inhibition of scrapie agent replication.

1993 ◽  
Vol 67 (10) ◽  
pp. 6270-6272 ◽  
Author(s):  
B Caughey ◽  
D Ernst ◽  
R E Race
Keyword(s):  
Congo Red ◽  
Scrapie Agent ◽  
Agent Replication

scholarly journals Amphotericin B delays both scrapie agent replication and PrP-res accumulation early in infection.

1994 ◽  
Vol 68 (11) ◽  
pp. 7534-7536 ◽  
Author(s):  
D McKenzie ◽  
J Kaczkowski ◽  
R Marsh ◽  
J Aiken
Keyword(s):  
Amphotericin B ◽  
Scrapie Agent ◽  
Agent Replication

scholarly journals SCID mouse spleen does not support scrapie agent replication

1994 ◽  
Vol 75 (6) ◽  
pp. 1511-1514 ◽  
Author(s):  
K. I. O'Rourke ◽  
T. P. Huff ◽  
C. W. Leathers ◽  
M. M. Robinson ◽  
J. R. Gorham
Keyword(s):  
Scid Mouse ◽  
Mouse Spleen ◽  
Scrapie Agent ◽  
Agent Replication

scholarly journals Small critical RNAs in the scrapie agent

2009 ◽  
Author(s):  
Steve Simoneau ◽  
Marie-Madeleine Ruchoux ◽  
Nicolas Vignier ◽  
Pierre Lebon ◽  
Sophie Freire ◽  
...  
Keyword(s):  
Scrapie Agent

Sedimentation characteristics of the scrapie agent from murine spleen and brain

Biochemistry ◽  
1978 ◽  
Vol 17 (23) ◽  
pp. 4987-4992 ◽  
Author(s):  
Stanley B. Prusiner ◽  
William J. Hadlow ◽  
Carl M. Eklund ◽  
Richard E. Race ◽  
S. Patricia Cochran
Keyword(s):  
Scrapie Agent ◽  
Murine Spleen

Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue

1986 ◽  
Vol 883 (2) ◽  
pp. 173-177 ◽  
Author(s):  
R FARNDALE ◽  
D BUTTLE ◽  
A BARRETT
Keyword(s):  
Sulphated Glycosaminoglycans

scholarly journals The chemical nature of the scrapie agent

1969 ◽  
Vol 114 (2) ◽  
pp. 24P-25P ◽  
Author(s):  
D L Mould
Keyword(s):  
Chemical Nature ◽  
Scrapie Agent

scholarly journals Sulphated glycosaminoglycans and proteoglycans in the developing vertebral column of juvenile Atlantic salmon (Salmo salar)

2015 ◽  
Vol 41 (4) ◽  
pp. 1029-1051 ◽  
Author(s):  
Kirsten O. Hannesson ◽  
Elisabeth Ytteborg ◽  
Harald Takle ◽  
Grethe Enersen ◽  
Grete Bæverfjord ◽  
...  
Keyword(s):  
Atlantic Salmon ◽  
Salmo Salar ◽  
Vertebral Column ◽  
Atlantic Salmon Salmo Salar ◽  
Juvenile Atlantic Salmon ◽  
Sulphated Glycosaminoglycans
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