scholarly journals Expression of the NUP98 /HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15)

2000 ◽  
Vol 109 (2) ◽  
pp. 423-426 ◽  
Author(s):  
Katsuya Yamamoto ◽  
Yuichi Nakamura ◽  
Yuko Nakamura ◽  
Kenji Saito ◽  
Shinpei Furusawa
Keyword(s):  
Chronic Myelogenous Leukaemia ◽  
Blast Crisis ◽  
Philadelphia Chromosome ◽  
Fusion Transcript ◽  
Myelogenous Leukaemia ◽  
Philadelphia Chromosome Positive

A study of prognostic factors in blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia

1990 ◽  
Vol 76 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Francisco Cervantes ◽  
María Rozman ◽  
Jordi Rosell ◽  
Alvaro Urbano-Ispizua ◽  
Emilio Montserrat ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Chronic Myelogenous Leukaemia ◽  
Blast Crisis ◽  
Philadelphia Chromosome ◽  
Myelogenous Leukaemia ◽  
Philadelphia Chromosome Positive

The role of the c- oncogene in Philadelphia chromosome positive chronic myelogenous leukaemia

1987 ◽  
Vol 23 (11) ◽  
pp. 1756
Author(s):  
Gerard C. Grosveld ◽  
Andre B.C. Hermans ◽  
Annelies de Klein ◽  
Dirk Bootsma ◽  
Nora Heisterkamp ◽  
...  
Keyword(s):  
Chronic Myelogenous Leukaemia ◽  
Philadelphia Chromosome ◽  
Myelogenous Leukaemia ◽  
Philadelphia Chromosome Positive

scholarly journals P210 and P190 BCR-ABL fusion transcripts variants frequencies among Philadelphia chromosome-positive chronic myeloid leukemia in Sudan

2018 ◽  
Vol 9 (5) ◽  
pp. 172
Author(s):  
Abdalla Abdelrahman Ahmed Elnour ◽  
Mahdi H.A. Abdalla
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Mononuclear Cells ◽  
Chronic Myelogenous Leukaemia ◽  
Fusion Gene ◽  
Philadelphia Chromosome ◽  
Chronic Phase ◽  
Fusion Transcript ◽  
Specific Primers ◽  
Transcript Variants

Breakpoint cluster region-abelson (BCR-ABL) leukemic fusion gene types in chronic myeloid leukemia (CML) correlate with the disease clinical course and outcome. There are variations in the reports of previous studies about the frequencies and distribution of BCR-ABL transcripts in chronic myelogenous leukaemia among Sudanese patients. This research aims to determine the frequencies of BCR-ABL fusion transcript variants in Sudan. One hundred (informed consent) Philadelphia positive chronic myeloid leukaemia patients, in chronic phase, were enrolled in this study. EDTA anticoagulated peripheral blood samples were collected from each participant, RNA was extracted from mononuclear cells by (TRIzol) reagent. BCR-ABL transcripts were detected by qRT-PCR technique with specific primers forP190 and P210 BCR-ABL transcript variants. The typical p210 BCR-ABL transcripts (b3a2 or b2a2) were detected in all patients (100%) the b3a2 transcript was detected in 96/100 (96%) and the b2a2 transcript was detected in 4/100 (4%).co-expression of p210/p190 (b2a3/e1a2) was detected in 6/100 (6%). p190 variant was not detected independently. 

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