Green tea catechin improves microsomal phospholipase A2 activity and the arachidonic acid cascade system in the kidney of diabetic rats

2002 ◽  
Vol 11 (3) ◽  
pp. 226-231 ◽  
Author(s):  
Soon-Jae Rhee ◽  
Jeong-Hwa Choi ◽  
Mo Ra Park
Keyword(s):  
Arachidonic Acid ◽  
Phospholipase A2 ◽  
Green Tea ◽  
Diabetic Rats ◽  
Arachidonic Acid Cascade ◽  
Cascade System ◽  
Green Tea Catechin ◽  
Phospholipase A2 Activity

scholarly journals Vitamin E Improves Microsomal Phospholipase A2 Activity and the Arachidonic Acid Cascade in Kidney of Diabetic Rats

2001 ◽  
Vol 131 (4) ◽  
pp. 1297-1301 ◽  
Author(s):  
Oh-Gye Kwag ◽  
Sung-Ok Kim ◽  
Jeong-Hwa Choi ◽  
In-Koo Rhee ◽  
Myung-Sook Choi ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Vitamin E ◽  
Phospholipase A2 ◽  
Diabetic Rats ◽  
Arachidonic Acid Cascade ◽  
Phospholipase A2 Activity

Arachidonic acid analogues as inhibitors of phospholipase A2 activity

1987 ◽  
Vol 15 (3) ◽  
pp. 418-419 ◽  
Author(s):  
KEITH A FOSTER ◽  
DEREK R. BUCKLE ◽  
KIM L. CRESCENZI ◽  
ASHLEY E. FENWICK ◽  
JOHN E. TAYLOR
Keyword(s):  
Arachidonic Acid ◽  
Phospholipase A2 ◽  
Phospholipase A2 Activity

NMDA receptors activate the arachidonic acid cascade system in striatal neurons

Nature ◽  
1988 ◽  
Vol 336 (6194) ◽  
pp. 68-70 ◽  
Author(s):  
A. Dumuis ◽  
M. Sebben ◽  
L. Haynes ◽  
J. -P. Pin ◽  
J. Bockaert
Keyword(s):  
Arachidonic Acid ◽  
Nmda Receptors ◽  
Arachidonic Acid Cascade ◽  
Striatal Neurons ◽  
Cascade System

scholarly journals The localization of phospholipase A2 in the secretory granule

1994 ◽  
Vol 300 (3) ◽  
pp. 619-622 ◽  
Author(s):  
S P Chock ◽  
E A Schmauder-Chock ◽  
E Cordella-Miele ◽  
L Miele ◽  
A B Mukherjee
Keyword(s):  
Arachidonic Acid ◽  
Phospholipase A2 ◽  
Secretory Granule ◽  
Secretory Granules ◽  
Lipid Mediator ◽  
Arachidonic Acid Cascade ◽  
Surface Receptors ◽  
The Matrix ◽  
Immunocytochemical Techniques ◽  
Granule Matrix

A heat-resistant phospholipase A2 has been detected in the secretory granules of the mast cell [Chock, Rhee, Tang and Schmauder-Chock (1991) Eur. J. Biochem. 195, 707-713]. By using ultrastructural immunocytochemical techniques, we have now localized this enzyme to the matrix of the secretory granule. Like the cyclo-oxygenase [Schmauder-Chock and Chock (1989) J. Histochem. Cytochem. 37, 1319-1328], this enzyme also adheres tightly to the ribbon-like granule matrix components. The results from Western-blot analysis suggest that it has a molecular mass of about 14 kDa. The localization of the phospholipase A2, the presence of a phospholipid store with millimolar concentrations of calcium and the localization of the enzymes of the arachidonic acid cascade make the secretory granule a natural site for lipid-mediator synthesis. The packaging of phospholipase A2, together with its substrate and the components of the arachidonic acid cascade, in the secretory granule represents a physical arrangement by which the initiation of the cascade and the release of mediators can be directly linked to the stimulation of cell-surface receptors.

The coumarin derivative AD6 inhibits the release of arachidonic acid by interfering with phospholipase A2 activity in human platelets stimulated with thrombin

1990 ◽  
Vol 29 (3-4) ◽  
pp. 364-373 ◽  
Author(s):  
S. Porcellati ◽  
V. Costantini ◽  
M. Prosdocimi ◽  
M. Stasi ◽  
R. Pistolesi ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Phospholipase A2 ◽  
Coumarin Derivative ◽  
Human Platelets ◽  
Phospholipase A2 Activity
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