scholarly journals Les sénolytiques contre la Covid-19 ?

2021 ◽  
Vol 37 (11) ◽  
pp. 1062-1065
Author(s):  
Bertrand Jordan
Keyword(s):  
Clinical Trials ◽  
Viral Infection ◽  
Clinical Application ◽  
Phase Ii ◽  
Exposure System ◽  
Phase Ii Clinical Trials ◽  
Coronavirus Infection ◽  
Effects Of Aging ◽  
Old Mice ◽  
Ongoing Phase

The elimination of some senescent cells by « senolytic » compounds can greatly improve the health of aged mice and in some cases reverse the effects of aging. Using a microbial exposure system that closely models coronavirus infection, it is possible to largely protect old mice from the effects of viral infection. This immediately suggests clinical application of the approach, and is the aim of ongoing phase II clinical trials in Covid-19 patients.

Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity

2020 ◽  
Vol 20 (19) ◽  
pp. 2019-2035
Author(s):  
Esmaeil Sheikh Ahmadi ◽  
Amir Tajbakhsh ◽  
Milad Iranshahy ◽  
Javad Asili ◽  
Nadine Kretschmer ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Biological Activity ◽  
Small Molecules ◽  
Anticancer Activity ◽  
Clinical Significance ◽  
Phase Ii ◽  
Biological Activities ◽  
Phase Ii Clinical Trials ◽  
Naturally Occurring ◽  
The Subject

Naturally occurring naphthoquinones (NQs) comprising highly reactive small molecules are the subject of increasing attention due to their promising biological activities such as antioxidant, antimicrobial, apoptosis-inducing activities, and especially anticancer activity. Lapachol, lapachone, and napabucasin belong to the NQs and are in phase II clinical trials for the treatment of many cancers. This review aims to provide a comprehensive and updated overview on the biological activities of several new NQs isolated from different species of plants reported from January 2013 to January 2020, their potential therapeutic applications and their clinical significance.

Properties of HIV envelope expressed in the presence of SPC3, an Env-derived peptide drug under phase II clinical trials

2009 ◽  
Vol 52 (4) ◽  
pp. 283-288 ◽  
Author(s):  
R. Barbouche ◽  
E. Fenouillet ◽  
M.-J. Papandréou ◽  
M.P. Kiény ◽  
J M. Sabatier
Keyword(s):  
Clinical Trials ◽  
Phase Ii ◽  
Peptide Drug ◽  
Phase Ii Clinical Trials ◽  
Hiv Envelope
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