Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder

2001 ◽  
Vol 120 (2) ◽  
pp. 354-360 ◽  
Author(s):  
Ernest P. Bouras ◽  
Michael Camilleri ◽  
Duane D. Burton ◽  
George Thomforde ◽  
Sanna McKinzie ◽  
...  
2011 ◽  
Vol 140 (5) ◽  
pp. S-710
Author(s):  
Maria I. Vazquez-Roque ◽  
Johanna Iturrino ◽  
Michael Camilleri ◽  
Richard J. Seime ◽  
Jill Snuggerud ◽  
...  

2021 ◽  
Vol 116 (1) ◽  
pp. S220-S220
Author(s):  
Yamen Ezaizi ◽  
Mhd Louai Manini ◽  
Kristin Mara ◽  
Michael Camilleri

2002 ◽  
Vol 283 (2) ◽  
pp. G384-G389 ◽  
Author(s):  
Ngai-Moh Law ◽  
Adil E. Bharucha ◽  
Alan R. Zinsmeister

Colonic transit is slowed in patients with disordered rectal evacuation, but the mechanism of this phenomenon is unclear. Our objective was to investigate rectocolonic inhibitory reflexes in humans to provide potential insight into patients with obstructed defecation. In 30 healthy subjects, a barostat-manometric assembly recorded colonic tone and phasic activity in the descending colon during rectal distension and recorded rectal tone during colonic distension. Phasic distensions were 8, 16, and 32 mmHg above balloon operating pressure, and staircase inflations were comprised of balloon inflation then deflation in 2-mmHg increments at 30-s intervals from 0 to 36 mmHg. Colonic balloon volumes increased to a similar extent during phasic rectal distensions 8, 16, and 32 mmHg above operating pressure, reflecting reduced colonic tone; balloon volumes also increased and phasic pressure activity decreased during staircase rectal distensions. In contrast, rectal balloon volume declined, reflecting increased tone during phasic and staircase colonic distensions. Thus rectal distension inhibited colonic motor activity, indicative of a viscerovisceral inhibitory reflex.


2013 ◽  
Vol 144 (5) ◽  
pp. S-724-S-725
Author(s):  
Gururaj J. Kolar ◽  
Duane D. Burton ◽  
Ashley Nadeau ◽  
Jong Chul Rhee ◽  
Alan R. Zinsmeister ◽  
...  

2014 ◽  
Vol 2 (1) ◽  
pp. 38-46 ◽  
Author(s):  
Priya Vijayvargiya ◽  
Johanna Iturrino ◽  
Michael Camilleri ◽  
Andrea Shin ◽  
Maria Vazquez-Roque ◽  
...  

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