143: Oral Sodium Phosphate Laxative Associated Acute Renal Failure

2008 ◽  
Vol 51 (4) ◽  
pp. B63
Author(s):  
Kelly Liang ◽  
Iasmina Craici ◽  
Kianoush Kashani ◽  
Hatem Amer ◽  
John Dillon
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Sodium Phosphate ◽  
Oral Sodium Phosphate ◽  
Oral Sodium

Acute renal failure following oral sodium phosphate bowel preparation: a nationwide case-crossover study

Endoscopy ◽  
2014 ◽  
Vol 46 (06) ◽  
pp. 465-470 ◽  
Author(s):  
Nam-Kyong Choi ◽  
Joongyub Lee ◽  
Yoosoo Chang ◽  
Ye-Jee Kim ◽  
Ju-Young Kim ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Crossover Study ◽  
Bowel Preparation ◽  
Sodium Phosphate ◽  
Case Crossover ◽  
Oral Sodium Phosphate ◽  
Oral Sodium

scholarly journals A brief grief over bowel relief

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 26 ◽  
Author(s):  
Kamalpreet S Parmar ◽  
Malvinder S Parmar
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Kidney Disease ◽  
Bowel Preparation ◽  
Sodium Phosphate ◽  
Careful Monitoring ◽  
Oral Sodium Phosphate ◽  
Oral Sodium

Oral sodium phosphate (OSP) solution is commonly used as bowel purgative before colonoscopy. Its safety has recently been questioned with several reports of acute renal failure and chronic kidney disease following its use. All of the cases reported are following bowel preparation for colonoscopy. I present a case of acute renal failure following OSP solution given to relieve constipation. This report further highlights the dangers of OSP and the importance of caution and careful monitoring when OSP solution is used as a cathartic, or for bowel preparation before colonoscopy.

Acute Renal Failure Following Oral Sodium Phosphate Bowel Preparation in Diabetes

Diabetes Care ◽  
2006 ◽  
Vol 30 (1) ◽  
pp. 182-183 ◽  
Author(s):  
R. C.W. Ma ◽  
C. C. Chow ◽  
V. T.F. Yeung ◽  
W. Y. So ◽  
A. P.S. Kong ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Bowel Preparation ◽  
Sodium Phosphate ◽  
Oral Sodium Phosphate ◽  
Oral Sodium

scholarly journals Findings of Biopsy-Proven Chronicity and End-Stage Renal Failure Associated with Oral Sodium Phosphate Solution

Renal Failure ◽  
2012 ◽  
Vol 34 (4) ◽  
pp. 499-501 ◽  
Author(s):  
Mustafa Cakar ◽  
Mehmet Kanbay ◽  
Hakan Sarlak ◽  
Muharrem Akhan ◽  
Mahmut Gok ◽  
...  
Keyword(s):  
Renal Failure ◽  
Sodium Phosphate ◽  
Phosphate Solution ◽  
End Stage Renal Failure ◽  
Sodium Phosphate Solution ◽  
Oral Sodium Phosphate ◽  
End Stage ◽  
Oral Sodium ◽  
Oral Sodium Phosphate Solution

Renal failure due to acute nephrocalcinosis following oral sodium phosphate bowel cleansing

2004 ◽  
Vol 35 (6) ◽  
pp. 675-684 ◽  
Author(s):  
Glen S Markowitz ◽  
Samih H Nasr ◽  
Philip Klein ◽  
Herman Anderson ◽  
Jay I Stack ◽  
...  
Keyword(s):  
Renal Failure ◽  
Sodium Phosphate ◽  
Bowel Cleansing ◽  
Oral Sodium Phosphate ◽  
Oral Sodium

Renal Failure and Nephrocalcinosis Associated With Oral Sodium Phosphate Bowel Cleansing: Clinical Patterns and Renal Biopsy Findings

2006 ◽  
Vol 130 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Gulfiliz Gonlusen ◽  
Hulya Akgun ◽  
Atilla Ertan ◽  
Juan Olivero ◽  
Luan D. Truong
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Renal Biopsy ◽  
Bowel Preparation ◽  
Sodium Phosphate ◽  
Renal Tubules ◽  
Tubulointerstitial Injury ◽  
Bowel Cleansing ◽  
Oral Sodium Phosphate ◽  
Oral Sodium

Abstract Acute renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of renal disease, and with normal baseline renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A renal biopsy showed multifocal calcium phosphate deposition in the renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for renal biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The renal failure improved at least partially in most of these patients, but persisted in rare cases.

scholarly journals Use of Oral Sodium Phosphate Colonic Lavage Solution by Canadian Colonoscopists: Pitfalls and Complications

1997 ◽  
Vol 11 (4) ◽  
pp. 334-338 ◽  
Author(s):  
A Chan ◽  
W Depew ◽  
S Vanner
Keyword(s):  
Renal Failure ◽  
Patient Group ◽  
Sodium Phosphate ◽  
Significant Proportion ◽  
Attractive Alternative ◽  
Colonic Lavage ◽  
Canadian Association ◽  
Oral Sodium Phosphate ◽  
Lavage Solution ◽  
Oral Sodium

Oral sodium phosphate (NaP) has become an attractive alternative to polyethylene glycol (PEG) for colonic cleansing before colonoscopy, but it potentially has greater complications. This study surveyed members of the Canadian Association of Gastroenterology (CAG) to determine how these colonic lavage agents are used and what complications have been encountered. The Dillman survey technique produced responses from 67% of the 400 members who perform colonoscopy. For the larger out-patient group, respondents used NaP more frequently than PEG (46% versus 35%, respectively, P<0.015). Respondents used NaP and PEG with similar frequencies for the in-patient group (44% versus 43%). Of respondents using NaP, 45% reported excluding its use in patients with renal failure, 30% with heart disease, 13% with incomplete bowel obstruction and 9% with extreme age. Symptoms suggestive of hypovolemia were reported in 9% of those using NaP compared with 3% using PEG (P<0.02). Three patients receiving NaP developed acute renal failure. A greater proportion of those using NaP had small unexplained aphthous ulcers (16%) and excessive luminal bubbling (24%) compared with PEG users (3%, P<0.00001 and 14%, P<0.03, respectively). These data demonstrate that members of CAG use NaP more frequently than PEG as the colonic lavage solution before colonoscopy. A greater number reported complications with NaP versus PEG, and a significant proportion of the respondents appeared to be unaware of the potential for these complications in specific clinical circumstances.

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