136 A Rare Case of Fibrillary Glomerulonephritis in a Patient with Gastric Adenocarcinoma

Fibrillary glomerulonephritis (FGN) and complement 3 glomerulopathy (C3G) are rare forms of glomerulonephritis with distinct aetiologies. Both FGN and C3G can present with nephritic syndrome. FGN is associated with autoimmune disease, dysproteinaemia, malignancy and hepatitis C infection. C3G is caused by the unregulated activation of the alternative complement pathway. We present a rare case of diffuse necrotising crescentic glomerulonephritis with dominant C3 glomerular staining on immunofluorescence—consistent with C3G—but electron microscopy (EM) findings of randomly oriented fibrils with a mean diameter of 14 nm and positive immunohistochemistry for DNAJB9—suggestive of FGN. To the best of our knowledge, this is the first reported case of FGN to show dominant C3 glomerular deposits. This case report reaffirms the utility of EM in the evaluation of nephritic syndrome and highlights the value of DNAJB9—a novel biomarker with a sensitivity and specificity near 100% for FGN.

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Extremely high expression of serum alpha-fetoprotein level of gastric adenocarcinoma: a rare case with an unexpected well-prognosis

SpringerPlus ◽

10.1186/s40064-016-3719-7 ◽

2016 ◽

Vol 5 (1) ◽

Author(s):

Weihua Gong ◽

Dawei Shou ◽

Ping Gong

Keyword(s):

Gastric Adenocarcinoma ◽

Rare Case ◽

Alpha Fetoprotein ◽

High Expression ◽

Serum Alpha Fetoprotein

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Splenic metastasis from gastric adenocarcinoma: A rare case

International Journal of Surgery Case Reports ◽

10.1016/j.ijscr.2014.10.094 ◽

2015 ◽

Vol 7 ◽

pp. 119-123 ◽

Cited By ~ 2

Author(s):

Marco Santos ◽

Vilma Martins ◽

Filipa Moreno ◽

J. Ramón Vizcaíno ◽

Isabel Mesquita

Keyword(s):

Gastric Adenocarcinoma ◽

Rare Case ◽

Splenic Metastasis

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A Rare Case of Fibrillary Glomerulonephritis Presenting with Hemoptysis

American Journal of Kidney Diseases ◽

10.1053/j.ajkd.2017.02.188 ◽

2017 ◽

Vol 69 (4) ◽

pp. A61

Keyword(s):

Rare Case ◽

Fibrillary Glomerulonephritis

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Amyotropic lateral sclerosis as a para-neoplastic manifestation of gastric adenocarcinoma - A rare case report

International Journal of Medical Science and Public Health ◽

10.5455/ijmsph.2014.090120141 ◽

2014 ◽

Vol 3 (3) ◽

pp. 380

Author(s):

Subrata Chakrabarti ◽

Koushik Pan

Keyword(s):

Case Report ◽

Gastric Adenocarcinoma ◽

Rare Case ◽

Amyotropic Lateral Sclerosis ◽

Rare Case Report ◽

Lateral Sclerosis

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A Rare Case of an Advanced Gastric Adenocarcinoma in a Teenage Syrian Boy

Case Reports in Oncological Medicine ◽

10.1155/2018/9140593 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4

Author(s):

Baraa Daboul ◽

Ahmad Ghazal ◽

Ayham Al Halak ◽

Sabah Hayed ◽

Yasmin Najjar

Keyword(s):

Gastric Cancer ◽

Gastric Adenocarcinoma ◽

Rare Case ◽

Palliative Therapy ◽

Delayed Diagnosis ◽

Exploratory Laparotomy ◽

Feeding Jejunostomy ◽

Multiple Biopsies ◽

Advanced Gastric Adenocarcinoma ◽

To Receive

In this report, we describe a case of a gastric cancer in young age group with delayed diagnosis and poor prognosis. We report a rare case of a 16-year-old teenager with an advanced moderately differentiated gastric adenocarcinoma without any relevant history. He presented mainly with dysphagia, postprandial vomiting, and eventually hematemesis. On exploratory laparotomy, the tumor was in advanced stage, the excision was not performed, multiple biopsies and a feeding jejunostomy were done, and the patient was referred to receive a palliative therapy. Reporting such cases introduces a better understanding of the relation between gastric cancer and young ages.

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