Arterial versus venous sampling for activated coagulation time measurements during cardiac surgery: A comparative study

2004 ◽  
Vol 18 (5) ◽  
pp. 573-580 ◽  
Author(s):  
Galina Leyvi ◽  
Ilya Zhuravlev ◽  
Asuquo Inyang ◽  
Joselito Vinluan ◽  
Sujatha Ramachandran ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Comparative Study ◽  
Venous Sampling ◽  
Coagulation Time ◽  
Activated Coagulation Time

In Vivo Protamine Titration Using Activated Coagulation Time to Neutralize Heparin Anticoagulation in Cardiac Surgery: Proof of Concept

2020 ◽  
Vol 34 (9) ◽  
pp. 2369-2374
Author(s):  
Antoine G. Rochon ◽  
Sylvain Bélisle ◽  
Pierre Couture ◽  
Annik Fortier ◽  
Jean-Sébastien Lebon ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Proof Of Concept ◽  
Coagulation Time ◽  
Heparin Anticoagulation ◽  
Activated Coagulation Time

Use of Activated Coagulation Time to Monitor Heparin during Cardiac Surgery

1979 ◽  
Vol 28 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Jack A. Roth ◽  
Ramon A. Cukingnan ◽  
Calvin R. Scott
Keyword(s):  
Cardiac Surgery ◽  
Coagulation Time ◽  
Activated Coagulation Time

A Comparison of Activated Coagulation Time–Based Techniques for Anticoagulation During Cardiac Surgery With Cardiopulmonary Bypass

2008 ◽  
Vol 22 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Robert D. Slight ◽  
Rivan Buell ◽  
Onyekwelu C. Nzewi ◽  
David B.L. McClelland ◽  
Pankaj S. Mankad
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Coagulation Time ◽  
Activated Coagulation Time

High Molecular Weight Kininogen Deficiency: a Patient who Underwent Cardiac Surgery

2001 ◽  
Vol 85 (02) ◽  
pp. 195-197 ◽  
Author(s):  
J. F. Burman ◽  
L. C. Rutherford ◽  
B. F. Keogh ◽  
M. H. Yacoub ◽  
S. J. Davidson
Keyword(s):  
Molecular Weight ◽  
Cardiac Surgery ◽  
High Molecular Weight ◽  
High Molecular Weight Kininogen ◽  
Coagulation Time ◽  
Chromogenic Assay ◽  
Thrombotic Complications ◽  
Pulmonary Bypass ◽  
Activated Coagulation Time ◽  
Protamine Administration

SummaryA 66 year old male, referred for cardiac surgery, was found to have high molecular weight kininogen deficiency (activity <1%). Apart from activated partial thromboplastin time (APTT) >300 s, tests of haemostasis were otherwise normal (factors VIII, IX, XI, XII and prekallikrein). No inhibitor of coagulation was found.The activated coagulation time (ACT) was 800 s pre-operatively and >1000 s after heparin. Heparin levels were measured directly by an anti-Xa chromogenic assay, with values of between 2.9 and 3.2 u/ml during cardiopulmonary bypass. Thrombin-antithrombin levels rose from 2.3*g/l before surgery to a peak of 83.5*g/l at the end of cardio-pulmonary bypass. Cross linked fibrin d-dimers (XDP) levels rose from 100 ng/ml before operation to 600 ng/ml after protamine administration. The patient had no excess bleeding and no thrombotic complications from surgery.This patient shows that high molecular weight kininogen is not required for thrombin formation or fibrinolysis during cardiac surgery and illustrates the need to measure heparin directly in patients with such contact factor deficiencies.

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