Combined intra-arterial and intravenous chemotherapy may prolong time to recurrence after hepatic resection of colorectal cancer

2002 ◽  
Vol 3 (4) ◽  
pp. 159-161
Author(s):  
Alan Venook
Keyword(s):  
Colorectal Cancer ◽  
Hepatic Resection ◽  
Intravenous Chemotherapy ◽  
Time To Recurrence

Combined-Modality Treatment for Resectable Metastatic Colorectal Carcinoma to the Liver: Surgical Resection of Hepatic Metastases in Combination With Continuous Infusion of Chemotherapy—An Intergroup Study

2002 ◽  
Vol 20 (6) ◽  
pp. 1499-1505 ◽  
Author(s):  
M. Margaret Kemeny ◽  
Sudeshna Adak ◽  
Bruce Gray ◽  
John S. Macdonald ◽  
Thomas Smith ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatic Resection ◽  
Continuous Infusion ◽  
Median Survival ◽  
Hepatic Metastases ◽  
Combined Modality Treatment ◽  
Long Term Outcome ◽  
Chemotherapy Group ◽  
Time To Recurrence ◽  
Free Rate

PURPOSE: Despite technical improvements that have minimized the morbidity and mortality of hepatic surgery, the long-term outcome of resection of hepatic metastases of colorectal cancer remains poor, with the majority of patients experiencing treatment failure in the liver. Because arterial chemotherapy regimens targeted to the liver have demonstrated high response rates, an intergroup trial of adjuvant therapy for patients undergoing hepatic resection of liver metastases from colorectal cancer was initiated. PATIENTS AND METHODS: Patients with one to three potentially resectable metastases were randomized preoperatively to receive no further therapy (control arm, 56 patients) or postoperative hepatic arterial floxuridine combined with intravenous continuous-infusion fluorouracil (chemotherapy arm, 53 patients). After exclusion of patients identified as ineligible for the planned treatment at the time of surgery, there were 45 control patients and 30 on the chemotherapy arm. The study was powered to evaluate improvement in time to recurrence and hepatic disease-free survival, not overall survival. RESULTS: The 4-year recurrence-free rate was 25% for the control arm and 46% for the chemotherapy group (P = .04). The 4-year liver recurrence-free rate was 43% in the control group and 67% in the chemotherapy group (P = .03). The median survival of the 75 assessable patients was 49 months for the control arm and 63.7 months for the chemotherapy arm (P = .60). The median survival of all 109 patients was 47 months for the control arm compared with 34 months for the chemotherapy arm (P = .19) CONCLUSION: These data demonstrate that adjuvant intra-arterial and intravenous chemotherapy was beneficial in prolonging time to recurrence and pre-venting hepatic recurrence after hepatic resection of colorectal cancer.

The survival after recurrence of colorectal cancer: a retrospective study focused on time to recurrence after curative resection

Surgery Today ◽  
2021 ◽  
Author(s):  
Hirotaka Furuke ◽  
Tomohiro Arita ◽  
Yoshiaki Kuriu ◽  
Hiroki Shimizu ◽  
Jun Kiuchi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Curative Resection ◽  
Time To Recurrence

scholarly journals Chemotherapy-Induced Splenic Volume Increase Is Independently Associated with Major Complications after Hepatic Resection for Metastatic Colorectal Cancer

2015 ◽  
Vol 220 (3) ◽  
pp. 271-280 ◽  
Author(s):  
Amber L. Simpson ◽  
Julie N. Leal ◽  
Amudhan Pugalenthi ◽  
Peter J. Allen ◽  
Ronald P. DeMatteo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatic Resection ◽  
Metastatic Colorectal Cancer ◽  
Splenic Volume ◽  
Volume Increase ◽  
Major Complications

Analysis of Prognostic Factors Influencing Long-term Survival After Hepatic Resection for Metastatic Colorectal Cancer

2007 ◽  
Vol 32 (1) ◽  
pp. 93-103 ◽  
Author(s):  
Marcella Arru ◽  
Luca Aldrighetti ◽  
Renato Castoldi ◽  
Saverio Di Palo ◽  
Elena Orsenigo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Hepatic Resection ◽  
Metastatic Colorectal Cancer ◽  
Term Survival ◽  
Long Term Survival ◽  
Factors Influencing

scholarly journals Recurrence Patterns after Hepatic Resection for Metastases from Colorectal Cancer.

1997 ◽  
Vol 30 (3) ◽  
pp. 735-740
Author(s):  
Hidenobu Masui ◽  
Hideyuki Ike ◽  
Shinji Togo ◽  
Shigeki Yamaguchi ◽  
Syouichi Fujii ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatic Resection ◽  
Recurrence Patterns

Repeated hepatic resection for recurrent metastases from colorectal cancer

1992 ◽  
Vol 79 (2) ◽  
pp. 146-148 ◽  
Author(s):  
F. Bozzetti ◽  
P. Bignami ◽  
F. Montalto ◽  
R. Doci ◽  
L. Gennari
Keyword(s):  
Colorectal Cancer ◽  
Hepatic Resection

scholarly journals Change in circulating tumor DNA after hepatic resection for metastatic colorectal cancer

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S25
Author(s):  
R.R. Narayan ◽  
M.L. Babicky ◽  
D.A. Goldman ◽  
M. Gonen ◽  
P.J. Allen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatic Resection ◽  
Metastatic Colorectal Cancer ◽  
Circulating Tumor Dna ◽  
Tumor Dna

scholarly journals Simultaneous laparoscopic colorectal and hepatic resection for patients with colorectal cancer and synchronous liver metastases: a multicenter series

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S968
Author(s):  
M. van der Poel ◽  
P. Tanis ◽  
A. Rijken ◽  
E. Gertsen ◽  
M. Gerhards ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Hepatic Resection ◽  
Synchronous Liver Metastases

From scratch: developing a hepatic resection service for metastatic colorectal cancer

2016 ◽  
Vol 88 (5) ◽  
pp. E377-E381
Author(s):  
Neil Wylie ◽  
Phillip Hider ◽  
Delwyn Armstrong ◽  
Kheman Rajkomar ◽  
Sanket Srinivasa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatic Resection ◽  
Metastatic Colorectal Cancer
Sign in / Sign up

Export Citation Format

Share Document