Synthesis of Chiral o-Aminobenzylamines via a Stereoselective Addition of Grignard Reagents to o-Aminosulfinylimine

Synlett ◽  
2021 ◽  
Author(s):  
Xianqiang Zhong ◽  
Guorong Xiao ◽  
Wei Zhou
Keyword(s):  
Asymmetric Synthesis ◽  
Grignard Reagent ◽  
Chiral Ligands ◽  
Grignard Reagents ◽  
Highly Efficient ◽  
Stereoselective Addition

Chiral o-aminobenzylamines are synthons for many chiral ligands and catalysts which have been widely used in asymmetric synthesis. Herein, we report a highly efficient and stereoselective addition of Grignard reagent to o-aminosulfinylimine for a range of o-aminosulfinylimines in good yields with good to excellent diastereoselectivity.

Aziridine ring-containing chiral ligands as highly efficient catalysts in asymmetric synthesis

2013 ◽  
Vol 24 (7) ◽  
pp. 421-425 ◽  
Author(s):  
Michał Rachwalski ◽  
Szymon Jarzyński ◽  
Stanisław Leśniak
Keyword(s):  
Asymmetric Synthesis ◽  
Chiral Ligands ◽  
Aziridine Ring ◽  
Highly Efficient

Strategies of In Situ Generated Magnesium Catalysis in Asymmetric Reactions

Synlett ◽  
2021 ◽  
Author(s):  
Dongxu Yang ◽  
Linqing Wang
Keyword(s):  
Asymmetric Synthesis ◽  
Alkaline Earth ◽  
Earth Metal ◽  
Asymmetric Reactions ◽  
Chiral Ligands ◽  
Alkaline Earth Metal ◽  
Enantioselective Reactions ◽  
Earth's Crust

AbstractMagnesium (Mg) is a cheap, non-toxic, and recyclable alkaline earth metal that constitutes about 2% weight in the Earth’s crust. The use of magnesium catalysts to forge chiral moieties in molecules is highly attractive. Based on our work in recent years, we describe the current progress in the development of in situ generated magnesium catalysts and their application in asymmetric synthesis. In this perspective, a critically concise classification of in situ generated magnesium catalytic modes, with relevant examples, is presented, and representative mechanisms of each category are discussed. Building on the established diverse strategies, one can foresee that more innovative and structurally creative magnesium catalysts that are generated in situ will be developed to overcome more formidable challenges of catalytic enantioselective reactions.1 Introduction2 Magnesium Catalysts Generated in Situ from Chiral Ligands Containing Dual Reactive Hydrogens3 Magnesium Catalysts Generated in Situ from Monoanionic Chiral Ligands4 Bimetallic and Polymetallic Magnesium Catalysts Assembled in Situ5 Summary and Outlook

New camphor derived chiral ligands for asymmetric synthesis

1998 ◽  
Vol 9 (22) ◽  
pp. 4009-4020 ◽  
Author(s):  
Max Knollmüller ◽  
Mathias Ferencic ◽  
Peter Gärtner ◽  
Kurt Mereiter ◽  
Christian R. Noe
Keyword(s):  
Asymmetric Synthesis ◽  
Chiral Ligands
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