An Efficient Protocol for the Synthesis of pyrazolo[1,5-c]quinazolines via Staudinger-Aza-Wittig-Dehydroaromatization Sequence

Synlett ◽  
2021 ◽  
Author(s):  
Mingxian Xu ◽  
An Chen ◽  
Zhilin Ren ◽  
Jiying Qiu ◽  
Mingming Zu ◽  
...  
Keyword(s):  
Hydrazine Hydrate ◽  
Acyl Chloride ◽  
One Pot ◽  
One Pot Synthesis

One-pot synthesis of azide-substituted dihydropyrazoles in isopropanol was performed using chalcones, hydrazine hydrate, and acyl chloride at 0℃, and its subsequent Staudinger-aza-Wittig-dehydroaromatization reactions with methyldiphenylphosphine were also investigated for further application in the construction of pyrazolo[1,5-c]quinazolines.

One-pot synthesis of β-ketosulfones from sulfonyl chloride, hydrazine hydrate and vinyl azide in water

Tetrahedron ◽  
2020 ◽  
Vol 76 (48) ◽  
pp. 131635
Author(s):  
Yaohong Zhang ◽  
Mengqiang Luo ◽  
Yan Li ◽  
Runfu Shen ◽  
Chenze Qi ◽  
...  
Keyword(s):  
Hydrazine Hydrate ◽  
Sulfonyl Chloride ◽  
One Pot ◽  
One Pot Synthesis

A Novel and Convenient Synthesis of 3-Amino-2H-1,2,4-Triazoles from Isoselenocyanates and Hydrazine Hydrate

2018 ◽  
Vol 42 (5) ◽  
pp. 255-259
Author(s):  
Xue Li ◽  
Zhixiang Peng ◽  
Yuanyuan Zhang ◽  
Jiangwei Wang ◽  
Bin Gan ◽  
...  
Keyword(s):  
Hydrazine Hydrate ◽  
Aromatic Amine ◽  
Atom Economy ◽  
One Pot ◽  
One Pot Synthesis ◽  
Convenient Synthesis ◽  
Plausible Mechanism

A novel and convenient one-pot synthesis of 3-amino-2 H-1,2,4-triazoles from two molecules of isoselenocyanates and hydrazine hydrate via cyclodeselenisation was developed. Various 3-amino-2 H-1,2,4-triazoles were obtained in moderate to good yields (33–45%, based on isoselenocyanates). The selenium powder and aromatic amine side products during the reaction could be recycled for efficient preparation of isoselenocyanates, which improved the atom economy. A plausible mechanism was proposed for the formation of the target products.

One pot synthesis of aromatic azide using sodium nitrite and hydrazine hydrate

2013 ◽  
Vol 54 (10) ◽  
pp. 1294-1297 ◽  
Author(s):  
Afsar Ali Siddiki ◽  
Balaram S. Takale ◽  
Vikas N. Telvekar
Keyword(s):  
Hydrazine Hydrate ◽  
Sodium Nitrite ◽  
One Pot ◽  
One Pot Synthesis ◽  
Aromatic Azide

Two Efficient One-Pot Approaches for Regioselective Synthesis of New 3-Arylpyridazino[4,3-c]quinolin-5(6H)-ones

2015 ◽  
Vol 68 (10) ◽  
pp. 1529 ◽  
Author(s):  
Mehdi Rimaz
Keyword(s):  
Hydrazine Hydrate ◽  
Regioselective Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
The One ◽  
High Yields ◽  
Arylglyoxal Monohydrates ◽  
Operational Simplicity

Two efficient regioselective approaches for the one-pot synthesis of 3-arylpyridazino[4,3-c]quinolin-5(6H)-one derivatives are reported, by the three-component reaction of arylglyoxal monohydrates, quinoline-2,4-diol, and hydrazinium dihydrochloride or hydrazine hydrate in ethanol and pyridine. In ethanol, the reactions were catalyzed by 1,4-diazobicyclo[2,2,2]octane. The features of both procedures are high regioselectivity, mild reaction conditions, good to high yields, and operational simplicity.

Synthesis of 1-aryl-2,4,10a-Triazaphenanthrene-3-Selones Via a Three-Component Condensation of Isoquinolin-1-Amine, Potassium Selenocyanate and an Acyl Chloride

2018 ◽  
Vol 42 (3) ◽  
pp. 145-147 ◽  
Author(s):  
Sonia Singh ◽  
Mohammad H. Mosslemin ◽  
Alireza Hassanabadi
Keyword(s):  
Room Temperature ◽  
Acyl Chloride ◽  
One Pot ◽  
One Pot Synthesis ◽  
Benzoyl Chlorides

A simple, one-pot synthesis of six 1-aryl-2,4,10a-triazaphenanthrene-3-selones has been achieved with moderate to good yields via a three-component condensation of isoquinolin-1-amine, potassium selenocyanate and variously substituted benzoyl chlorides in acetone at room temperature.

A Concise One-Pot Synthesis of 3,4-Diaryl-1H-pyrazoles from Natural Isoflavones and Hydrazine Hydrate

2007 ◽  
Vol 90 (11) ◽  
pp. 2096-2108 ◽  
Author(s):  
Zun-Ting Zhang ◽  
Da-Jin Tan ◽  
Dong Xue
Keyword(s):  
Hydrazine Hydrate ◽  
One Pot ◽  
One Pot Synthesis
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