Controllable Preparation and Rapid Photoelectric Response of Homogeneous ZnTe Microspheres

With the use of ethylene glycol as a solvent, polyvinylpyrrolidone as a surfactant and hydrazine hydrate as a reducing agent, uniform spherical ZnTe microstructure was synthesized in a homogeneous reactor...

MoS2 QDs/8-Armed Poly(Ethylene Glycol) Fluorescence Sensor for Three Nitrotoluenes (TNT) Detection

In this work, ammonia cross-linked 8-armed polyethylene glycol hydrogel material was successfully synthesized and used as a template for synthesizing nanoparticles with fluorescent properties. The 8-armed polyethylene glycol hydrogel template was used to prepare molybdenum disulfide quantum dots (MoS2 QDs). The ammonium tetrathiomolybdate functioned as a molybdenum source and hydrazine hydrate functioned as a reducing agent. The fluorescence properties of the as-prepared MoS2 QDs were investigated. The bursting of fluorescence caused by adding different concentrations of explosive TNT was studied. The study indicated that the synthesized MoS2 QDs can be used for trace TNT detection with a detection limit of 6 nmol/L and a detection range of 16–700 nmol/L. Furthermore, it indicated that the fluorescence-bursting mechanism is static bursting.

Synthesis, Characterization of Novel Schiff’s Bases of 2-(1H-tetrazol-5-yl) Pyridine and Evaluation of their Antitubercular Activity

This study aimed to prepare some new 2-(1H-tetrazol-5-yl) pyridine derivatives from Pyridine Nitrile as a starting materials and to evaluate the antitubercular activity against Mycobacterium Tuberculosis. The first step involves the reaction of 2-(1H-tetrazol-5-yl) pyridine with ethyl chloroacetate to form ethyl [5-(pyridin-2-yl)-1H-tetrazol-1-yl] acetate (A). In step II it was further treated with hydrazine hydrate to form 2-[5-(pyridin-2-yl)-1H-tetrazol-1-yl] acetohydrazide (B). The compound B was treated with different aromatic aldehyde to form N'-[(E)-substituted phenylmethylidene]-2-[5-(pyridin-2-yl)-1H-tetrazol-1-yl] acetohydrazide (Schiff Bases) (C1–C10). The compounds obtained were identified by spectral data. The antitubercular activity of synthesized compounds were evaluated against Mycobacterium Tuberculosis. The compound C4 and C10 was found to possess potent activity while compounds C2 and C3 shows moderate activity.

Synthesis, in vitro Antioxidant Activity, and Toxicity Evaluation of Hydrazone Derivatives Naphthalene-1-ylmethylene hydrazine

Hydrazone is a versatile organic compound that has a basic structure (-NHN=CH-) called the azomethine group. This structure is responsible for the physical and chemical of hydrazone, which makes this compound has variety bioactivities such as antioxidant, antitumor, and anticancer. In this work, two hydrazone derivatives from 1-naphthaldehyde and hydrazine (phenylhydrazine/hydrazine hydrate) have been synthesized under microwave irradiation. Their antioxidant activity and toxicity were evaluated by DPPH and BSLT method, respectively. Structures of the synthesized compounds were confirmed based on spectroscopic data included UV, FTIR, HRMS, and 1H-NMR. Based on the DPPH assay, hydrazone from phenylhydrazine has strong antioxidant (IC50 28.90 μg/mL) but inactive antioxidant for hydrazine hydrate (IC50 >1000 μg/mL). However, both compounds have a high toxicity effect on Artemia Salina Leach with each LC50 1.45 and 47.20 μg/mL, hence they have the potential to be developed into anticancer drugs.

Synthesis of Schiff’s Bases of 1,2,4-Triazole Derivatives under Microwave Irradiation Technique and Evaluation of Their Anti-diabetic Activity

Background: Schiff bases play key role for the generation of a large number of biologically active compounds via cycloaddition, replacement and ring closure reactions. Objective: The objective of this study is to optimize the purity and yield of product, reaction time, eco-friendly reaction by the help of microwave assisted organic synthesis. Methods: New series of Schiff’s bases of triazole derivatives were achieved via multicomponent reactions. The starting material benzohydrazide 1 was obtained by esterification of bezoyl chloride with methanol in presence of concentrated sulphuric acid followed by the reaction with hydrazine hydrate. Benzohydrazide was allowed to react with carbon disulphide in ethanolic potassium hydroxide solution to yield potassium dithiocarbazinate 2 which undergoes cyclization by reacting with hydrazine hydrate to afford 4-[amino]-5-phenyl-4H-1,2,4-triazole-3-thiol (3). Further, various Schiff’s bases 4a-f were obtained by reacting 1,2,4-triazole-3-thiol with different substituted benzaldehydes under microwave irradiations as a green and eco-friendly energy source. Results: The structures of the newly synthesized compounds were elucidated in accordance with their spectral data and elemental analysis. Conclusion : The obtained compounds exhibited significant in-vivo anti-diabetic activity as compared to the standard drug Metformin. The anti-diabetic effect was investigated by using Alloxan-induced diabetic model.

Reducing of Sterically Hindered Pyridine Substituted Para-Nitrosophenols

Reduction of para-nitrosopyridylphenols with hydrazine hydrate in ethanol made it possible to obtain previously unavailable per-substituted para-aminophenols with pyridine substituents. The structure of the compounds obtained for the first time was confirmed by IR, 1H NMR spectroscopy and mass spectrometry

An Efficient Protocol for the Synthesis of pyrazolo[1,5-c]quinazolines via Staudinger-Aza-Wittig-Dehydroaromatization Sequence

One-pot synthesis of azide-substituted dihydropyrazoles in isopropanol was performed using chalcones, hydrazine hydrate, and acyl chloride at 0℃, and its subsequent Staudinger-aza-Wittig-dehydroaromatization reactions with methyldiphenylphosphine were also investigated for further application in the construction of pyrazolo[1,5-c]quinazolines.