Eupatorium perfoliatum L.: Antiinflammatory and antiplasmodial activity of the dichloromethane extract and novel sesquiterpene lactones

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
M Maas ◽  
F da Costa ◽  
A Deters ◽  
T Schmidt ◽  
A Hensel
Keyword(s):  
Sesquiterpene Lactones ◽  
Antiplasmodial Activity ◽  
Eupatorium Perfoliatum

scholarly journals Antiplasmodial activity of sesquiterpene lactones and a sucrose ester from Vernonia guineensis Benth. (Asteraceae)

2013 ◽  
Vol 147 (3) ◽  
pp. 618-621 ◽  
Author(s):  
Ngeh J. Toyang ◽  
Michael A. Krause ◽  
Rick M. Fairhurst ◽  
Pierre Tane ◽  
Joseph Bryant ◽  
...  
Keyword(s):  
Sesquiterpene Lactones ◽  
Sucrose Ester ◽  
Antiplasmodial Activity

scholarly journals In VitroAntiplasmodial Activity of Sesquiterpene Lactones fromAmbrosia tenuifolia

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
V. Sülsen ◽  
D. Gutierrez Yappu ◽  
L. Laurella ◽  
C. Anesini ◽  
A. Gimenez Turba ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Active Compound ◽  
Inhibitory Concentration ◽  
Sesquiterpene Lactones ◽  
Lymphoid Cells ◽  
Antiplasmodial Activity ◽  
Organic Extract

Thein vitroantiplasmodial activity ofAmbrosia tenuifoliaorganic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated againstPlasmodium falciparumF32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain ofP. falciparumwith a 50% inhibitory concentration value (IC50) of 0.3 μg/mL (1.1 μM) whereas psilostachyin showed activity on both strains (IC50= 0.6 (2.1 μM) and 1.8 μg/mL (6.4 μM)). Fifty percent cytotoxic concentration (CC50) values (48 h) were 6.8 μg/mL (24.3 μM) and 10.0 μg/mL (37.9 μM) for psilostachyin and peruvin, respectively.

scholarly journals Isolation and Antimalarial Activity of a New Flavonol from Tithonia diversifolia Leaf Extract

Chemistry ◽  
2021 ◽  
Vol 3 (3) ◽  
pp. 854-860
Author(s):  
Talkmore Ngarivhume ◽  
Anwar Noreljaleel ◽  
Susana L. Bonnet ◽  
Ankie Wilhelm
Keyword(s):  
Leaf Extract ◽  
Antimalarial Activity ◽  
Sesquiterpene Lactones ◽  
Sensitive Strain ◽  
Antiplasmodial Activity ◽  
Tithonia Diversifolia

An antiplasmodial activity-guided isolation was carried out on the dichloromethane extract of Tithonia diversifolia dried leaves. A total of five germacranolide type sesquiterpene lactones and a new flavonol, 3,6-dihydroxy-2-(4′-hydroxyphenyl)-7-methoxy-4H-chromen-4-one, were isolated. The flavonol reported an IC50 above 6.00 µM against the chloroquine sensitive strain, NF54. The antimalarial activity of the Tithonia diversifolia dichloromethane leaf extract was attributed to orizabin and tagitinin C.

ChemInform Abstract: SESQUITERPENE LACTONES OF EUPATORIUM PERFOLIATUM

1977 ◽  
Vol 8 (42) ◽  
pp. no-no
Author(s):  
W. HERZ ◽  
P. S. KALYANARAMAN ◽  
G. RAMAKRISHNAN ◽  
J. F. BLOUNT
Keyword(s):  
Sesquiterpene Lactones ◽  
Eupatorium Perfoliatum

An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatorium perfoliatum

2011 ◽  
Vol 72 (7) ◽  
pp. 635-644 ◽  
Author(s):  
Mareike Maas ◽  
Andreas Hensel ◽  
Fernando Batista da Costa ◽  
Reto Brun ◽  
Marcel Kaiser ◽  
...  
Keyword(s):  
Sesquiterpene Lactones ◽  
Antiprotozoal Activity ◽  
Eupatorium Perfoliatum

Sesquiterpene lactones of Eupatorium perfoliatum

1977 ◽  
Vol 42 (13) ◽  
pp. 2264-2271 ◽  
Author(s):  
Werner Herz ◽  
Palaiyur S. Kalyanaraman ◽  
Ganapathy Ramakrishnan ◽  
John F. Blount
Keyword(s):  
Sesquiterpene Lactones ◽  
Eupatorium Perfoliatum

scholarly journals Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L.

2011 ◽  
Vol 133 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Rocky Graziose ◽  
Thirumurugan Rathinasabapathy ◽  
Carmen Lategan ◽  
Alexander Poulev ◽  
Peter J. Smith ◽  
...  
Keyword(s):  
Sesquiterpene Lactones ◽  
Liriodendron Tulipifera ◽  
Antiplasmodial Activity
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