Catalytic Asymmetric Synthesis of syn Aldols with Methyl Ketone Functionality and anti Aldols with a Thioamide Group

Synlett ◽  
2019 ◽  
Vol 30 (05) ◽  
pp. 620-624 ◽  
Author(s):  
Naoya Kumagai ◽  
Masakatsu Shibasaki ◽  
Yuya Ota ◽  
Zhao Li

Catalytic asymmetric syntheses of syn aldols with a methyl ketone functionality were studied to confirm the generality of the methodology. In addition, catalytic asymmetric synthesis of anti aldols with a thioamide group was carefully examined, giving the desired products, albeit with moderate diastereoselectivity.

2007 ◽  
Vol 119 (6) ◽  
pp. 995-997 ◽  
Author(s):  
Elaine C. Lee ◽  
Kevin M. McCauley ◽  
Gregory C. Fu

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