Zr-Catalyzed Microwave Assisted Functionalization of Alkyne and Nitroalkene

Water and zirconium(IV) as catalyst were found to be effective in the transformation of terminal aromatic alkyne to aromatic methyl ketone in the microwave. This terminal alkyne hydration reaction proceeded in excellent yield with Zr(cp)2Cl2. The reaction was moved efficiently in presence of electron donating or electron withdrawing substituent on aromatic ring. An eco-friendly synthesis of aldehyde by oxidative cleavage of nitroalkene was developed with Zr(cp)2Cl2 catalyst and water in microwave.

Unified Approach to ent-Eudesmane-type Terpenoid Synthesis: Total Synthesis of Sinupol and Eutyscoparin A

ent-Eudesmane-type terpenoids constitute a large class of natural products derived from plants, animals, and bacteria. We describe a synthetic approach to two ent-eudesmane-type terpenoids, sinupol, and eutyscoparin A, that relies on a key π-facial- and endo/exo-selective intramolecular Diels–Alder reaction to set the C-5–C-10 stereotriads. Further key transformations of trans-fused decalin include conversion to methyl ketone via a versatile thioester intermediate and appropriate functionalization toward target compounds.

Capillary Sensor for Detection of Amphetamine Precursors in Sewage Water

This paper deals with the problem of detecting benzyl methyl ketone (BMK), which is a precursor of amphetamine that can be synthesized in home labs. The focus of our work was to identify an improvement for the analysis of sewage introduced into the municipal sewage system. The sensors used to detect BKM in these systems are often clogged and therefore cannot function properly. In this article, a new method of detecting BMK and other chemicals in wastewater is presented. A system containing capillary polypropylene, hydrophobized with polysiloxane coating fibers was prepared. These solutions were used for continuous online measurements by ion mobility spectrometry. The use of pipes with a polysiloxane coating reduces the permeation of water and significantly increases the BMK permeation due to its high solubility in the polymer.

Kajian Regiokimia Markovnikov Melalui Mekanisme Reaksi Hidrasi Alkuna Terminal pada Etinilestradiol dengan Katalis FeCl3

The terminal alkynes hydration reaction on 17α-ethynylestradiol (1) with FeCl3 catalyst mediated by dichloromethane aims to determine the reaction products produced and to conduct a Markovnikov regiochemistry study through the proposed reaction mechanism. The reaction conditions were carried out at a temperature of 50oC (48 hours) and 60oC (19 hours), the separation of the reaction properties was carried out using Gravity Column Chromatography, and the reaction products were identification using by Proton Nuclear Magnetic Resonance (1H-NMR). Here we describe the process of the FeCl3 catalyst forming a coordination complex with the terminal alkyne, which is then addition by nucleophilic water following Markovnikov's regiochemistry to finally produce the product of a methyl ketone, 17α-acetylestradiol (6). The catalyst used is a cationic ligand coordinate, where Fe3+ is a Lewis acid and Cl3- acts as a ligand. The dichloromethane solvent used can also increase the reaction rate.

Ligand-redox assisted nickel catalysis toward stereoselective synthesis of (n+1)-membered cycloalkanes from 1,n-diols with methyl ketones

A well-defined, bench-stable nickel catalyst is presented here, that can conduct double alkylation of a methyl ketone to realize a wide variety of cycloalkanes. The performance of the catalyst hinges...