Regioselective installation of enolizable ketones and unprotected mercaptoacetic acid into olefins using GO as phase transfer catalyst

We report herein unprecedented conjugate addition of enolizable ketones and unprotected mercaptoacetic acid to electron poor alkenes using graphene oxide as phase transfer catalyst. The envisaged protocol is versatile and...

Microwave assisted synthesis of benzimidazole derivatives using tetra butyl ammonium chloride as phase transfer catalyst, characterization, biological activities and molecular docking studies

Benzimidazole and its derivatives are of wide interest because of their diverse biological activity and clinical applications. The heterocyclic imidazole core is a common moiety in a large number of natural products and pharmacologically active compounds and because of that they are possessing inhibitory activity as well as favorable selectivity ratio. Benzimidazoles exhibit significant activities like anti-microbial, anti-viral, anti-diabetic, anti-cancer activity, numerous antioxidants, anti-parasitic, anti-helmintics, antiproliferative, anti-HIV, anti-convulsant, antiinflammatory, anti-hypertensive, anti-neoplastic, proton pump inhibitor and anti-trichinellosis. The synthesis of benzimidazole derivatives remains a focus of medicinal research. Here benzimidazole derivatives were synthesized using two phase system under microwave conditions using the phase transfer catalyst tetra butyl ammonium chloride (10% mol) in good yield. The molecular docking study against 4GQQ protein with synthesized benzimidazole derivatives was performed to see the necessary interactions responsible for anti-bacterial activity.

Asymmetric synthesis of 3-phenyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-3-carbonitriles catalysed by phase transfer catalyst derived from tert-leucine.

Chiral phase transfer catalysts derived from tert-leucine were synthesized and used in the aymmetric synthesis of 4-azaindoline derivatives. By this method, both enantiomers of corresponding products were obtained in excellent yield (up to 99%) with high enantioselectivity (up to 91% ee) and diastereoselectivity (up to >99: 1 dr).

Study on Phase Transfer Catalyst Used in the Synthesis of Sodium Isobutyl Xanthate

Xanthates are by far the most widely used collectors in the froth flotation beneficiation of sulfide ores. However, the xanthate production process suffers from low yield, low productivity, long reaction time and environmental pollution. To address these issues, an effective method was developed for the synthesis of xanthates using phase transfer catalyst. Sodium isobutyl xanthate was synthesized from isobutyl alcohol ((CH3)2CHCH2OH), sodium hydroxide (NaOH) and carbon disulfide (CS2) with dichloromethane (CH2Cl2) as solvent and cetyltrimethylammonium bromide (CTAB), cetyltrimethylammonium chloride (CTAC), tetrabutylammonium bromide (TBAB) and tetrabutylammonium chloride (TBAC) as phase transfer catalyst. The compound was characterized by elemental analysis, infrared spectrum, 1H NMR and 13C NMR. The influencing factors on the content and yield of sodium isobutyl xanthate including phase transfer catalyst type, phase transfer catalyst dosage and reaction time were studied by single-factor experiments. The influencing factors on the product purity and yield including reaction temperature, solvent volume, material ratio and rotating speed were studied by orthogonal experiments. The results showed that when the amount of TBAC was 3.0%malcohol, the reaction temperature was 35 °C, the solvent volume was 3.5 Valcohol, the rotating speed was 180 rpm, the reaction time was 4 h and the material ratio was n[(CH3)2CHCH2OH]:n(NaOH):n(CS2) = 1:1:1.10, the product yield could be up to 86.66% and the product purity reached 82.56%.

A Convenient Synthesis of Thiol, Trithiocarbonate and Disulfide

<div>Synthesis of unsymmetrical trithiocarbonate sulfonate salt, along with disulfide, thiol and</div><div>symmetrical trithiocarbonate from 3-mercapto-1-propane-sulfonicacid, sodium salt with, without</div><div>of phase transfer catalyst and under various reaction conditions are described. The obtained</div><div>compounds having divergent usefulness in RAFT polymerization, sulfonyl preparation and</div><div>having capable of binding in a multidentate fashion to soft transition metal ions.</div>

A Convenient Synthesis of Thiol, Trithiocarbonate and Disulfide

<div>Synthesis of unsymmetrical trithiocarbonate sulfonate salt, along with disulfide, thiol and</div><div>symmetrical trithiocarbonate from 3-mercapto-1-propane-sulfonicacid, sodium salt with, without</div><div>of phase transfer catalyst and under various reaction conditions are described. The obtained</div><div>compounds having divergent usefulness in RAFT polymerization, sulfonyl preparation and</div><div>having capable of binding in a multidentate fashion to soft transition metal ions.</div>