Regular prophylaxis with recombinant factor VIIa in a patient with severe congenital FVII deficiency

2008 ◽  
Vol 28 (S 01) ◽  
pp. S55-S55 ◽  
Author(s):  
P. Lages ◽  
R. Zimmermann ◽  
A. Huth-Kühne
Keyword(s):  
Recombinant Factor Viia ◽  
Factor Viia ◽  
Fvii Deficiency

Continuous infusion of recombinant factor VIIa for surgery in patients with deficiency of factor VII

2005 ◽  
Vol 94 (12) ◽  
pp. 1177-1180 ◽  
Author(s):  
Geir E. Tjønnfjord ◽  
Richard Wallensten ◽  
Uri Martinowitz ◽  
Gili Kenet ◽  
Sam Schulman
Keyword(s):  
Continuous Infusion ◽  
Recombinant Factor Viia ◽  
Factor Viia ◽  
Single Case ◽  
Thromboembolic Complication ◽  
Factor Vii ◽  
Recombinant Activated Factor Vii ◽  
Activated Factor Vii ◽  
Different Types ◽  
Fvii Deficiency

SummaryThe administration of recombinant activated factor VII (rFVIIa) by continuous infusion has provided a safe and convenient alternative to bolus injections in haemophiliacs with inhibitors, but it has only been reported in a single case with congenital factorVII (FVII) deficiency. The results of 12 consecutive surgical procedures in 7 patients with congenital FVII deficiency are reported here. rFVIIa was always given in continuous infusion, aiming at plasma FVII activity of 0.5 IU/mL. Treatment was given for 2 to 7 days with a mean total dose of 7.8 mg rFVIIa. Blood loss was as expected from the different types of procedures and the only thromboembolic complication was a superficial thrombophlebitis at the infusion site. This mode of substitution was therefore safe, effective and well tolerated.

Extrinsic Coagulation Pathway Inhibitor during Recombinant Factor VIIa Infusion

1989 ◽  
Vol 62 (04) ◽  
pp. 1146-1146 ◽  
Author(s):  
Per Morten Sandset ◽  
Ulrich Abildgaard ◽  
Ulla Hedner ◽  
Hans Johansson
Keyword(s):  
Recombinant Factor Viia ◽  
Factor Viia ◽  
Coagulation Pathway

Clinical Study of Recombinant Factor VIIa (NN-007) in Hemophilia Patients with Inhibitors

1994 ◽  
Vol 5 (3) ◽  
pp. 158-172 ◽  
Author(s):  
Hidehiko SAITO ◽  
Junki TAKAMATSU ◽  
Tadashi KAMIYA ◽  
Katsuyuki FUKUTAKE ◽  
Tetsuya YAMAGISHI ◽  
...  
Keyword(s):  
Clinical Study ◽  
Recombinant Factor Viia ◽  
Factor Viia
Sign in / Sign up

Export Citation Format

Share Document