Autoimmune disorders in patients with idiopathic thrombotic thrombocytopenic purpura

2012 ◽  
Vol 32 (S 01) ◽  
pp. S86-S89 ◽  
Author(s):  
M.-L. John ◽  
I. Scharrer
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Celiac Disease ◽  
General Population ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Patient Group ◽  
Lupus Erythematosus ◽  
Autoimmune Disorders ◽  
Prevalence Rates ◽  
Systemic Lupus ◽  
Thrombocytopenic Purpura

Summary76 German patients suffering from thrombotic thrombocytopenic purpura (TTP) were interrogated about the prevalence of cooccurring autoimmune disorders. In order to analyze a possible association of TTP with the questioned diseases, a comparison of prevalence rates between the patient group and the general population has been made for each disease. Results: Compared to the estimated prevalence rates, the statistical analysis revealed an unexpected high occurrence of the following disorders within the patient group: Hashimoto’s thyroiditis (23.5% within the patients compared to 0.7% within the general population, p<0.001), systemic lupus erythematosus (SLE) (6.5% in patients to 0.025% in the general population, p<0.001), immune thrombocytopenic purpura (ITP) (6.3% in patients to 0.02% in the general population, p < 0.001), psoriasis (9.4% in patients to 2.5% in the general population, p = 0.005) and celiac disease (3.1% in patients to 0.2% in the general population, p = 0.007). Conclusion: These findings confirm the mentioned tendency of autoimmune diseases to co-occur in one individual and argue once more for a genetic susceptibility in idiopathic TTP as well as in autoimmune disorders.

scholarly journals An Early Unexpected Immune Thrombotic Thrombocytopenic Purpura Relapse Associated with SARS-CoV-2 Infection: A Case Report and Literature Review

2021 ◽  
pp. 1-5
Author(s):  
Maya Kornowski Cohen ◽  
Liron Sheena ◽  
Yair Shafir ◽  
Vered Yahalom ◽  
Anat Gafter-Gvili ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Lupus Erythematosus ◽  
Response To Therapy ◽  
Intravascular Hemolysis ◽  
Systemic Lupus ◽  
Thrombocytopenic Purpura ◽  
History Of ◽  
Triggering Factor

SARS-CoV-2 has been reported as a possible triggering factor for the development of several autoimmune diseases and inflammatory dysregulation. Here, we present a case report of a woman with a history of systemic lupus erythematosus and antiphospholipid syndrome, presenting with concurrent COVID-19 infection and immune thrombotic thrombocytopenic purpura (TTP). The patient was treated with plasma exchange, steroids, and caplacizumab with initial good response to therapy. The course of both TTP and COVID-19 disease was mild. However, after ADAMTS-13 activity was normalized, the patient experienced an early unexpected TTP relapse manifested by intravascular hemolysis with stable platelet counts requiring further treatment. Only 3 cases of COVID-19 associated TTP were reported in the literature thus far. We summarize the literature and suggest that COVID-19 could act as a trigger for TTP, with good outcomes if recognized and treated early.

scholarly journals Thrombotic thrombocytopenic purpura and systemic lupus erythematosus.

1986 ◽  
Vol 45 (4) ◽  
pp. 319-322 ◽  
Author(s):  
D A Fox ◽  
J D Faix ◽  
J Coblyn ◽  
P Fraser ◽  
B Smith ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Thrombocytopenic Purpura

scholarly journals Thrombotic Thrombocytopenic Purpura in a Patient with Systemic Lupus Erythematosus

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Guavita-Navarro Diana ◽  
Cajamarca-Baron Jairo ◽  
Buitrago-Bohorquez Jhon ◽  
Gallego-Cardona Laura ◽  
Guevara Diana ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Thrombocytopenic Purpura

THROMBOTIC THROMBOCYTOPENIC PURPURA: A DIAGNOSTIC CHALLENGE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

2021 ◽  
Author(s):  
Rubens Bonfiglioli ◽  
Vanessa Félix Nascimento Coelho ◽  
Andreza Lamonica ◽  
Thais de Campos Ferreira Pinto
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Diagnostic Challenge ◽  
Thrombocytopenic Purpura

, , , ,

Systemic Lupus Erythematosus with Secondary Thrombotic Thrombocytopenic Purpura and Acute Parkinsonism: A Case Report

2022 ◽  
Vol 71 (12) ◽  
Author(s):  
Pooja Deepak ◽  
Roha Saeed Memon ◽  
Fizza Tariq ◽  
Hassan Ahmed ◽  
Shaheen Bhatti
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Lupus Erythematosus ◽  
Late Onset ◽  
Case Reports ◽  
Gastrointestinal Symptoms ◽  
Signs And Symptoms ◽  
Urgent Care ◽  
Systemic Lupus ◽  
Thrombocytopenic Purpura

Systemic lupus erythematosus (SLE) is an autoimmune disease that has certain characteristic features but can also present with misleading signs and symptoms especially when it is of late-onset. Various case reports address its association with thrombotic thrombocytopenic purpura (TTP), however, its association with parkinsonism remains unclear. We present the case of a 58-year-old male who reported with acute-onset parkinsonism along with some gastrointestinal symptoms. Detailed laboratory investigations unmasked the underlying SLE with an overlapping picture of TTP. This unusual presentation in a resource-constrained setting created challenges and subsequent delays in the diagnosis and management of the patient. Despite urgent care, the patient’s age, presence of overlapping conditions, and multi-organ involvement were some of the factors due to which the treatment failed and he could not survive. We report the association of SLE with secondary TTP and parkinsonism.

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