Pyrophosphate Scan of the Temporarily Ischemized Dog Myocardium

1981 ◽  
Vol 20 (06) ◽  
pp. 268-271
Author(s):  
J. Novák ◽  
J. Vižďa ◽  
J. Kubíček ◽  
P. Kafka ◽  
O. Veverková ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Histological Examination ◽  
Left Coronary Artery ◽  
Complete Occlusion ◽  
Transient Myocardial Ischemia ◽  
Ramus Interventricularis Anterior

In 9 dogs a transient myocardial ischemia was provoked using complete occlusion of the ramus interventricularis anterior of the left coronary artery. The occlusion was removed after 5, 10 or 15 min. Four hrs after removal of the occlusion a scan of the myocardium was carried out using 99mTc-labelled pyrophosphate. In 7 out of 9 dogs under study the scan was markedly positive, in 2 dogs negative. ECG demonstrated ischemic changes practically in all dogs; the changes became normal after removal of the occlusion, namely in 5 to 35 min. The histological examination of the tissue demonstrated in all 9 dogs only a slight impairment of the myocardium.

Effects of exercise on collateral development in myocardial ischemia in pigs

1984 ◽  
Vol 56 (3) ◽  
pp. 656-665 ◽  
Author(s):  
C. M. Bloor ◽  
F. C. White ◽  
T. M. Sanders
Keyword(s):  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Exercise Training ◽  
Collateral Circulation ◽  
Coronary Artery Stenosis ◽  
Arterial Stenosis ◽  
Collateral Flow ◽  
Circumflex Coronary Artery ◽  
Complete Occlusion ◽  
Collateral Development

To study the effects of exercise on collateral development in myocardial ischemia, we induced coronary arterial stenosis of the left circumflex coronary artery (LCCA) in 18 of 30 pigs. During that surgery, we identified the coronary bed at risk. Nine of these pigs were then subjected to 5 mo of exercise training on a treadmill. After exercise training, we determined regional collateral and myocardial blood flow using radiolabeled microspheres. At autopsy, all animals had complete occlusion of the LCCA. Infarct size in the exercise-trained pigs was significantly less than in the sedentary pigs (5.9 +/- 1.0 vs. 11.7 +/- 1.0% of the left ventricle). The exercise-trained animals had a greater increase in collateral flow, 35.1 +/- 3.0 vs. 28.7 +/- 4.1 ml X min-1 X 100 g-1, in the noninfarcted jeopardized zone of the LCCA bed. The major findings of the study were the following: 1) chronic coronary artery stenosis progressing to occlusion stimulated development of the collateral circulation and salvaged tissue in the jeopardized myocardium of an animal model with sparse collaterals; 2) development of the collateral circulation and tissue salvage is increased by exercise training; 3) collaterals develop primarily in or near the ischemic zone; and 4) all collateral beds develop a circumferential flow gradient following occlusion.

Activity of transient myocardial ischemia out of hospital in coronary artery disease and implications for management

1985 ◽  
Vol 56 (17) ◽  
pp. I19-I22 ◽  
Author(s):  
Michael B. Rocco ◽  
Stephen Campbell ◽  
Joan Barry ◽  
George Rebecca ◽  
Elizabeth Nabel ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Transient Myocardial Ischemia ◽  
Artery Disease

scholarly journals Mechanism of myocardial ischemia with an anomalous left coronary artery from the right sinus of Valsalva

2012 ◽  
Vol 144 (2) ◽  
pp. 402-408 ◽  
Author(s):  
Carlo R. Bartoli ◽  
William B. Wead ◽  
Guruprasad A. Giridharan ◽  
Sumanth D. Prabhu ◽  
Steven C. Koenig ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Left Coronary Artery ◽  
Sinus Of Valsalva ◽  
Anomalous Left Coronary Artery ◽  
The Right ◽  
Anomalous Left Coronary

Cardiac adrenergic innervation after instrumentation of the coronary artery in dog

1984 ◽  
Vol 246 (3) ◽  
pp. H459-H465 ◽  
Author(s):  
S. Dolezel ◽  
M. Gerova ◽  
B. Hartmannova ◽  
M. Dostal ◽  
H. Janeckova ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Left Coronary Artery ◽  
Surgical Intervention ◽  
Adrenergic Innervation ◽  
Histochemical Technique ◽  
Perivascular Nerves ◽  
Ramus Interventricularis Anterior

A fine methacrylate ring (not constricting the artery) was placed around the ramus interventricularis anterior (RIA) of the left coronary artery in dogs. By means of Falck's histochemical technique an extensive degeneration of the vasomotor and cardiomotor adrenergic innervation of ventricles was detected 14 days after the procedure. The innervation of atria remained intact. The surgical intervention as well as the scarring process (which compressed the conducting parts of axons composing the perivascular nerves) induced the degeneration. The results have important implications for experiments with instrumented arteries.

scholarly journals Circadian variation of transient myocardial ischemia in patients with coronary artery disease.

Circulation ◽  
1987 ◽  
Vol 75 (2) ◽  
pp. 395-400 ◽  
Author(s):  
M B Rocco ◽  
J Barry ◽  
S Campbell ◽  
E Nabel ◽  
E F Cook ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Circadian Variation ◽  
Transient Myocardial Ischemia ◽  
Artery Disease
Sign in / Sign up

Export Citation Format

Share Document