Sentinel node biopsy in breast cancer

SummaryThe international consensus conference from St. Gallen concerning the treatment of early breast cancer concluded in 2003, that sentinel node biopsy was now accepted as method allowing axillary staging in breast cancer. This procedure may avoid complete lymph node dissection in appropriate cases. Since numerous questions associated with the technique are still not defined and the procedure itself is not yet standardized, the German Society of Senology defined the conditions for the routine clinical use of sentinel node biopsy in an interdisciplinary consensus meeting.

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Abstract P1-01-28: Utility of 18F-Fluoro-Deoxyglucose Emisión Tomography/Computed and Sentinel Node Biopsy for Axillary Staging in Primary Breast Cancer. Roffo PET/CT 1 Trial

10.1158/0008-5472.sabcs10-p1-01-28 ◽

2010 ◽

Author(s):

CM Noblia ◽

CE Cresta Morgado ◽

ME Azar ◽

G Bruno ◽

C Gonzalez ◽

...

Keyword(s):

Breast Cancer ◽

Sentinel Node ◽

Sentinel Node Biopsy ◽

Primary Breast Cancer ◽

Axillary Staging ◽

Node Biopsy ◽

Pet Ct

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Abstract P4-02-11: Can preoperative axillary staging replace sentinel node biopsy? Comparison of preoperative axillary and final histologic nodal findings in 2108 patients with primary breast cancer

10.1158/1538-7445.sabcs19-p4-02-11 ◽

2020 ◽

Author(s):

Julia Caroline Radosa ◽

Martin Deeken ◽

Lisa Stotz ◽

Sarah Huwer ◽

Carolin Müller ◽

...

Keyword(s):

Breast Cancer ◽

Sentinel Node ◽

Sentinel Node Biopsy ◽

Primary Breast Cancer ◽

Axillary Staging ◽

Node Biopsy

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3–44 Upstaging and Improved Survival of Early Breast Cancer Patients after Implementation of Sentinel Node Biopsy for Axillary Staging

Breast Diseases A Year Book Quarterly ◽

10.1016/s1043-321x(07)80340-7 ◽

2007 ◽

Vol 18 (3) ◽

pp. 287-288

Author(s):

C. Laronga

Keyword(s):

Breast Cancer ◽

Sentinel Node ◽

Cancer Patients ◽

Sentinel Node Biopsy ◽

Early Breast Cancer ◽

Axillary Staging ◽

Breast Cancer Patients ◽

Node Biopsy

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The sensitivity of axillary staging when using sentinel node biopsy in breast cancer

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2003.09.014 ◽

2003 ◽

Vol 29 (10) ◽

pp. 849-853 ◽

Cited By ~ 18

Author(s):

M Leidenius ◽

L Krogerus ◽

T Toivonen ◽

E Leppänen ◽

K von Smitten

Keyword(s):

Breast Cancer ◽

Sentinel Node ◽

Sentinel Node Biopsy ◽

Axillary Staging ◽

Node Biopsy

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SPIO-enhanced MR imaging for axillary staging to avoid sentinel node biopsy in patients with breast cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.1103 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 1103-1103

Author(s):

Kazuyoshi Motomura ◽

Tetsuta Izumi ◽

Souichirou Tateishi ◽

Atsushi Noguchi ◽

Hiroshi Sumino ◽

...

Keyword(s):

Breast Cancer ◽

Mr Imaging ◽

Sentinel Node ◽

Sentinel Node Biopsy ◽

Signal Intensity ◽

Axillary Staging ◽

Sentinel Nodes ◽

Node Biopsy ◽

Imaging Results ◽

The Mean

1103 Background: We previously demonstrated the usefulness of SPIO-enhanced MR imaging for the detection of metastases in sentinel nodes localized by computed tomography (CT) lymphography (CT-LG) in patients with breast cancer (Ann Surg Oncol, 2011). These techniques have evolved and we report our most recent results of axillary staging using them. Methods: Previously unreported 87 consecutive patients with breast cancer and clinically negative nodes were enrolled in this study. Sentinel nodes identified by CT-LG were evaluated prospectively using SPIO-enhanced MR imaging. A node was considered non-metastatic if it showed a homogenous low signal intensity and metastatic if the entire node or a focal area did not show a low signal intensity on MR imaging. Sentinel nodes located by CT-LG were removed, and imaging results and histopathological findings were compared. Results: The mean patient age was 54.9 years (range, 34-77). Sentinel nodes were identified by CT-LG and removed successfully in all patients. The mean number of sentinel nodes identified by CT-LG was 1.16 (range, 1-2). Twenty of 22 patients with positive sentinel nodes definitively diagnosed by pathology demonstrated metastases on SPIO-enhanced MR imaging. Fifty-eight of 65 patients with negative sentinel nodes definitively diagnosed by pathology were non-metastatic on imaging studies. The sensitivity, specificity and accuracy of MR imaging for the diagnosis of sentinel node metastases were 91%, 89%, and 90%, respectively. Two patients whose metastases were not detected had micrometastases. No adverse events were associated with either CT or MR imaging. Conclusions: SPIO-enhanced MR imaging provided accurate axillary staging, and therefore sentinel node biopsy may not be necessary for most patients with breast cancer.

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