The Clinical Use of Factor IX Concentrates

1975 ◽  
Vol 33 (03) ◽  
pp. 403-404
Author(s):  
Rosemary Biggs
Keyword(s):  
Factor Ix ◽  
Clinical Use

A Comparison of the in Vitro and in Vivo Thrombogenic Activity of Factor IX Concentrates Using Stasis (Wessler) and Non-Stasis Rabbit Models

1980 ◽  
Vol 44 (02) ◽  
pp. 081-086 ◽  
Author(s):  
C V Prowse ◽  
A E Williams
Keyword(s):  
Platelet Rich Plasma ◽  
Thrombus Formation ◽  
Factor Ix ◽  
Coagulation System ◽  
In Vitro Tests ◽  
Clinical Use ◽  
Low Activity

SummaryThe thrombogenic effects of selected factor IX concentrates were evaluated in two rabbit models; the Wessler stasis model and a novel non-stasis model. Concentrates active in either the NAPTT or TGt50 in vitro tests of potential thrombogenicity, or both, caused thrombus formation in the Wessler technique and activation of the coagulation system in the non-stasis model. A concentrate with low activity in both in vitro tests did not have thrombogenic effects in vivo, at the chosen dose. Results in the non-stasis model suggested that the thrombogenic effects of factor IX concentrates may occur by at least two mechanisms. A concentrate prepared from platelet-rich plasma and a pyrogenic concentrate were also tested and found to have no thrombogenic effect in vivo.These studies justify the use of the NAPTT and TGt50 in vitro tests for the screening of factor IX concentrates prior to clinical use.

Preparation and Clinical Use of Factor IX Concentrate PPSB According to Soulier

Vox Sanguinis ◽  
1969 ◽  
Vol 16 (5) ◽  
pp. 398-411 ◽  
Author(s):  
C. Haanen ◽  
R. L. McShine ◽  
A. Kunst
Keyword(s):  
Factor Ix ◽  
Clinical Use

scholarly journals Development of a Sensitive and Rapid Chromogenic Factor IX Assay for Clinical Use

1990 ◽  
Vol 20 (5) ◽  
pp. 276-288
Author(s):  
R. Wagenvoord ◽  
H. Hendrix ◽  
T. Tran ◽  
H.C. Hemker
Keyword(s):  
Factor Ix ◽  
Clinical Use

Factor IX Concentrates for Clinical Use

1993 ◽  
Vol 19 (01) ◽  
pp. 25-36 ◽  
Author(s):  
Arthur Thompson
Keyword(s):  
Factor Ix ◽  
Clinical Use

Preparation and Clinical Use of Factor IX Concentrate PPSB According to Soulier

Vox Sanguinis ◽  
1969 ◽  
Vol 16 (4-5) ◽  
pp. 398-411
Author(s):  
C. Haanen ◽  
R.L. McShine ◽  
A. Kunst
Keyword(s):  
Factor Ix ◽  
Clinical Use

Small Scale Preparation and Clinical Use of Factor IX-Prothrombin Complex

Vox Sanguinis ◽  
1973 ◽  
Vol 25 (5) ◽  
pp. 426-441 ◽  
Author(s):  
T. W. Barrowcliffe ◽  
Penelope Stableforth ◽  
Katharine M. Dormandy
Keyword(s):  
Factor Ix ◽  
Small Scale ◽  
Clinical Use ◽  
Scale Preparation
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