scholarly journals Zinc Dust Mediated Peptide Synthesis from Fmoc-Amino Acid Chlorides and Amino Acid Hydrochlorides

Synfacts ◽  
2021 ◽  
Vol 17 (08) ◽  
pp. 0951
Keyword(s):  
Amino Acid ◽  
Peptide Synthesis ◽  
Zinc Dust ◽  
Acid Chlorides

scholarly journals Synthesis of peptides employing Fmoc-amino acid chlorides and commercial zinc dust

1998 ◽  
Vol 39 (52) ◽  
pp. 9769-9772 ◽  
Author(s):  
Hosahydya N. Gopi ◽  
Vommina V. Suresh Babu
Keyword(s):  
Amino Acid ◽  
Zinc Dust ◽  
Acid Chlorides

Total Synthesis of Cyclosporin O by Convergent Approach Employing Fmoc-Amino Acid Chlorides Mediated by Zinc Dust

2007 ◽  
Vol 72 (24) ◽  
pp. 9360-9363 ◽  
Author(s):  
Subramanyam J Tantry ◽  
Rao Venkataramanarao ◽  
Gundala Chennakrishnareddy ◽  
Vommina Venkata Sureshbabu
Keyword(s):  
Amino Acid ◽  
Total Synthesis ◽  
Zinc Dust ◽  
Acid Chlorides ◽  
Convergent Approach

scholarly journals Synthesis of TFA-protected α-Amino Acid Chloride via a Vilsmeier Reagent for Friedel–Crafts Acylation

2020 ◽  
Vol 17 (8) ◽  
pp. 645-653
Author(s):  
Zetryana Puteri Tachrim ◽  
Kazuhiro Oida ◽  
Fumina Ohashi ◽  
Natsumi Kurokawa ◽  
Lei Wang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Peptide Synthesis ◽  
1H Nmr ◽  
Acid Chloride ◽  
Coupling Agents ◽  
Acid Chlorides ◽  
Vilsmeier Reagent ◽  
Peptide Formation ◽  
Dimethylammonium Chloride ◽  
Reactive Coupling

α-Amino acid chlorides are reactive coupling agents in amide (peptide) formation. The Vilsmeier reagent ((chloromethylene)dimethylammonium chloride) offers a convenient way to prepare α-amino acid chlorides for peptide synthesis. Its use with N-trifluoracetyl (TFA)-protected isoleucine and allo-isoleucine is described. The 1H-NMR of the α-proton signal offers a convenient way to monitor the chirality retention in the acid chloride forming reaction and subsequent Friedel-Crafts acylation of arenes which result in α-amino acid aryl-ketone with no loss of chirality.

[(9-Fluorenylmethyl)oxy]carbonyl (Fmoc) amino acid chlorides in solid-phase peptide synthesis

1991 ◽  
Vol 56 (8) ◽  
pp. 2635-2642 ◽  
Author(s):  
Louis A. Carpino ◽  
Hann Guang Chao ◽  
Michael Beyermann ◽  
Michael Bienert
Keyword(s):  
Amino Acid ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Acid Chlorides

ChemInform Abstract: Synthesis of Peptides Employing Fmoc-Amino Acid Chlorides and Commercial Zinc Dust.

ChemInform ◽  
2010 ◽  
Vol 30 (13) ◽  
pp. no-no
Author(s):  
Hosahudya N. Gopi ◽  
Vommina V. Suresh Babu
Keyword(s):  
Amino Acid ◽  
Zinc Dust ◽  
Acid Chlorides

Use of Fmoc amino acid chlorides in peptide synthesis

Peptides ◽  
1988 ◽  
pp. 189-191 ◽  
Author(s):  
Michael Beyermann ◽  
Dörthe Granitza ◽  
Michael Bienert ◽  
Burghard Mehlis ◽  
Hartmut Niedrich ◽  
...  
Keyword(s):  
Amino Acid ◽  
Peptide Synthesis ◽  
Acid Chlorides

Use of N-Fmoc amino acid chlorides and 2-alkoxy-5(4H)- oxazolones in solid phase peptide synthesis

Peptides ◽  
1992 ◽  
pp. 564-565
Author(s):  
D. S. Perlow ◽  
P. D. Williams ◽  
R. D. Tung ◽  
R. M. Freidinger ◽  
F. M. F. Chen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Acid Chlorides

Application of cellulose paper as support material in simultaneous solid phase peptide synthesis

1989 ◽  
Vol 54 (6) ◽  
pp. 1746-1752 ◽  
Author(s):  
Jutta Eichler ◽  
Michael Beyermann ◽  
Michael Bienert
Keyword(s):  
Amino Acid ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Support Material ◽  
Acid Chlorides ◽  
Cellulose Paper ◽  
Protected Amino Acid ◽  
Model Peptides

Cellulose paper was esterified with Nα-Fmoc-protected amino acid chlorides providing a chemically stable segmental support, the utility of which for simultaneous solid phase peptide synthesis was demonstrated by the synthesis of several sets of model peptides following different synthetic strategies.

ChemInform Abstract: ((9-Fluorenylmethyl)oxy)carbonyl Amino Acid Chlorides in Solid-Phase Peptide Synthesis.

ChemInform ◽  
2010 ◽  
Vol 22 (39) ◽  
pp. no-no
Author(s):  
L. A. CARPINO ◽  
H. G. CAHO ◽  
M. BEYERMANN ◽  
M. BIENERT
Keyword(s):  
Amino Acid ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Acid Chlorides
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