Aromatic Nucleophilic Nitrogen-Nitrogen Exchange Reaction ofN,N-Dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine with Amino Acid Derivatives: A Facile Synthesis of Fluorine-Containing 1H-Benzo[g]indolines and 1H-Benzo[g]indoles

Synthesis ◽  
1989 ◽  
Vol 1989 (07) ◽  
pp. 550-552 ◽  
Author(s):  
Masaru Hojo ◽  
Ryōichi Masuda ◽  
Etsuji Okada ◽  
Hiroshi Miya
Keyword(s):  
Amino Acid ◽  
Exchange Reaction ◽  
Amino Acid Derivatives ◽  
Facile Synthesis ◽  
Nitrogen Exchange

Facile Synthesis of a “Ready to Use” Precursor of Porphobilinogen and Its Amino Acid Derivatives

2008 ◽  
Vol 73 (2) ◽  
pp. 764-767 ◽  
Author(s):  
Carole Pissot Soldermann ◽  
Ramakrishnan Vallinayagam ◽  
Manuel Tzouros ◽  
Reinhard Neier
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Facile Synthesis

Amino Acid Derivatives in Organic Synthesis, Part 4 [1]: Facile Synthesis of Heterocycles Containing a Glycine Residue

2000 ◽  
Vol 55 (1) ◽  
pp. 104-108 ◽  
Author(s):  
Laila M. Chabaka ◽  
Yehia A. Allam ◽  
Galal A. M. Nawwar
Keyword(s):  
Amino Acid ◽  
Organic Synthesis ◽  
Acid Group ◽  
The Other ◽  
Amino Acid Derivatives ◽  
Carboxylic Acid Group ◽  
Facile Synthesis ◽  
Peptide Linkage ◽  
Active Methylene Compounds ◽  
Active Methylene

Pyridines, thiazolopyridines and pyrazolopyrans containing glycinate residue were prepared by reacting N-cyanoacryloglycinate ylidenes with active methylene compounds via a Michael addition - intracyclization synthetic pathway.Simple routes for the synthesis of heterocycles with an amino acid residue were previously reported [1-3] as the incorportation of these residues improves the pharmacokinetics and toxicity of active compounds [4,5]. However, trials to deesterify these residues for coupling purposes were unsuccessful. So, we tried herein new approaches for synthesizing heterocyles carrying one or two glycine moieties with free carboxylic acid group to facilitate further peptide linkage [6] on one hand and on the other one could be able to form metal chelates, a property having a significant output on the toxicological behaviour [7]

ChemInform Abstract: Facile Synthesis of a “Ready to Use” Precursor of Porphobilinogen and Its Amino Acid Derivatives.

ChemInform ◽  
2008 ◽  
Vol 39 (21) ◽  
Author(s):  
Carole Soldermann-Pissot ◽  
Ramakrishnan Vallinayagam ◽  
Manuel Tzouros ◽  
Reinhard Neier
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Facile Synthesis
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