A simple and practical intermolecular Pummerer reaction using difluoroenol silyl ethers as nucleophiles is described. The protocol allows for highly efficient α-difluoroalkylation of a wide spectrum of alkyl sulfoxides.
Direct conversion of cellulose-derived levulinic acid into γ-valerolactone and γ-valerolactone into 1,4-pentanediol was carried out by chemoselective hydrogenation catalyzed through supported copper-catalysts.
The cleavage of alkyl ethers by hydrosilylation is a powerful synthetic tool for the generation of silyl ethers. Previous attempts to apply this transformation to carbohydrate derivatives have been constrained...
