CHRONIC CARBON MONOXIDE POISONING PRESENTING AS NEW DAILY PERSISTENT HEADACHE: A CASE REPORT AND REVIEW OF THE LITERATURE

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
FD Jacob ◽  
KM Barlow
2013 ◽  
Vol 5 (3) ◽  
pp. 13 ◽  
Author(s):  
Michael Andrew Meyer

Delayed post-hypoxic leukoencephalopathy is a rare clinical phenomenon usually observed in a small number of carbon monoxide poisoning survivors. A similar phenomenon is reported here in a patient who successfully recovered from a large overdose of diazepam and methadone, but then abruptly declined 3 weeks after the initial event. Magnetic resnance revealed confluent white matter hyperintensity on fluid-attenuated inversion recovery and T2 weighted sequences, and spectroscopy revealed elevated peaks in choline, creatinine, and lactate. Analysis and review of the literature suggests this phenomenon occurs on average about 19 days after the initial event. Although the pathophysiology remains obscure, it is noted here that the mean lucid interval coincides approximately with the replacement half-life for myelin related lipids and proteins.


2018 ◽  
Vol 45 (1) ◽  
pp. 83-87 ◽  
Author(s):  
Lon W. Keim ◽  
◽  
Sreekanth Koneru ◽  
Vesper Fe Marie Ramos ◽  
Najib Murr ◽  
...  

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