The Long-Term Sequelae of Severe Hypoglycemia on the Brain in Insulin-Dependent Diabetes Mellitus

1997 ◽  
Vol 29 (05) ◽  
pp. 197-202 ◽  
Author(s):  
P. Perros ◽  
B. Frier
Keyword(s):  
Diabetes Mellitus ◽  
Severe Hypoglycemia ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent ◽  
The Brain

Memory and insulin dependent diabetes mellitus (IDDM): Effects of childhood onset and severe hypoglycemia

1997 ◽  
Vol 3 (6) ◽  
pp. 509-520 ◽  
Author(s):  
TAMARA HERSHEY ◽  
SUZANNE CRAFT ◽  
NEIL BHARGAVA ◽  
NEIL H. WHITE
Keyword(s):  
Diabetes Mellitus ◽  
Medial Temporal Lobe ◽  
Declarative Memory ◽  
Severe Hypoglycemia ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Childhood Onset ◽  
Memory Functioning ◽  
Insulin Dependent

Previous studies of the neuropsychological consequences of insulin dependent diabetes mellitus (IDDM) have had mixed and often contradictory results, possibly due to the heterogeneity of the samples and neuropsychological measures, and a lack of specific hypotheses. In order to address this problem, we focused on the effect of severe hypoglycemia on memory functioning in a relatively homogeneous sample of childhood-onset IDDM patients. Given the deleterious effects of hypoglycemia on medial temporal lobe structures (e.g., hippocampus) and the relationship between medial temporal damage and declarative memory functioning, we hypothesized that those patients who had experienced severe hypoglycemia would demonstrate impaired declarative memory and spared nondeclarative memory functioning. Results of the study were generally consistent with this hypothesis, although some impact of hypoglycemia was observed on perceptual priming ability. (JINS, 1997, 3, 509–520.)

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