Determination of Soil-Shrinkage Curve Using Transient Water Evaporation Method

Domperidone is a prokinetic and antiemetic agent which has low bioavaibility. To increase the bioavaibility of drug, it can be modified into microsphere that can hold drug more longer in gastric to improve the bioavaibility. The microsphere preparation requires a polymer that can make matrix system to protect and deliver the drugs. Acrycoat S100 and HPMC K4M are the usual polymers that used for encapsulation and have biodegradable characteristic. The aim of this research is to know the comparison ability of two different polymers to entrapment the drug in microsphere. Microsphere domperidone made by solvent evaporation method in 6 formula. F1, F2 and F3 using 50 mg, 100 mg and 150 mg Acrycoat S100 polymer, while F4, F5 and F6 using 50 mg, 100 mg and 150 mg HPMC K4m polymer. The tests were conducted by the determination of the percentage of entrapment efficiency using UV spectrophotometer and evaluation of organoleptic, particle measurement and surface microsphere morphology. The results showed that F3 with Acrycoat S100 polymer has a greater entrapment efficiency of 78,712% ± 4,260% compared to the highest percentage efficiency of HPMC K4M polymer of 4,734±0,390.Key words: Acrycoat S100, domperidone, entrapment efficiency, HPMC K4M, microsphere

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Discussion of “Generalized Equation for Soil Shrinkage Curve” by Pan Chen and Ning Lu

Journal of Geotechnical and Geoenvironmental Engineering ◽

10.1061/(asce)gt.1943-5606.0002059 ◽

2019 ◽

Vol 145 (7) ◽

pp. 07019011

Author(s):

E. C. Leong ◽

M. Wijaya

Keyword(s):

Generalized Equation ◽

Shrinkage Curve ◽

Soil Shrinkage

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Quantification of the effects of zero and mechanical tillage on a vertisol by using shrinkage curve indexes

Soil Research ◽

10.1071/sr9880537 ◽

1988 ◽

Vol 26 (3) ◽

pp. 537 ◽

Cited By ~ 13

Author(s):

D Mcgarry

Keyword(s):

Surface Layer ◽

Bulk Density ◽

Specific Volume ◽

Shrinkage Curve ◽

Soil Shrinkage ◽

Straight Lines

The effect of zero versus mechanical tillage on the structure of the top 0.1 m of a Vertisol at Hermitage, near Warwick, Queensland, was examined by using indices derived from fitting three straight lines to soil shrinkage data. The data were generated from the slow drying of initially, near-saturated, SARAN-coated soil clods. Values of specific volume and the specific volume of air-filled pores were significantly greater in the mechanically tilled rather than the zero-tilled soil, showing that mechanical tillage has led to decreased bulk density and increased porosity in the surface layer of this soil.

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