Power law kinetics in reversible enzyme-catalyzed reaction due to diffusion

2003 ◽  
Vol 119 (6) ◽  
pp. 3501-3508 ◽  
Author(s):  
Sujata Paul ◽  
Gautam Gangopadhyay
Keyword(s):  
2018 ◽  
Vol 115 (3) ◽  
pp. 513-518 ◽  
Author(s):  
Iris Grossman-Haham ◽  
Gabriel Rosenblum ◽  
Trishool Namani ◽  
Hagen Hofmann

Protein dynamics are typically captured well by rate equations that predict exponential decays for two-state reactions. Here, we describe a remarkable exception. The electron-transfer enzyme quiescin sulfhydryl oxidase (QSOX), a natural fusion of two functionally distinct domains, switches between open- and closed-domain arrangements with apparent power-law kinetics. Using single-molecule FRET experiments on time scales from nanoseconds to milliseconds, we show that the unusual open-close kinetics results from slow sampling of an ensemble of disordered domain orientations. While substrate accelerates the kinetics, thus suggesting a substrate-induced switch to an alternative free energy landscape of the enzyme, the power-law behavior is also preserved upon electron load. Our results show that the slow sampling of open conformers is caused by a variety of interdomain interactions that imply a rugged free energy landscape, thus providing a generic mechanism for dynamic disorder in multidomain enzymes.


1988 ◽  
Vol 27 (1) ◽  
pp. 191-194 ◽  
Author(s):  
Patrick L. Mills ◽  
Steven Lai ◽  
Milorad P. Dudukovic ◽  
Palghat A. Ramachandran

2017 ◽  
Vol 56 (2) ◽  
pp. 358-394 ◽  
Author(s):  
Dylan Antonio S. J. Talabis ◽  
Carlene Perpetua P. Arceo ◽  
Eduardo R. Mendoza
Keyword(s):  

1997 ◽  
Vol 151 (2) ◽  
pp. 443-460 ◽  
Author(s):  
F. Rosowski ◽  
A. Hornung ◽  
O. Hinrichsen ◽  
D. Herein ◽  
M. Muhler ◽  
...  

10.1114/1.105 ◽  
1998 ◽  
Vol 26 (5) ◽  
pp. 775-779 ◽  
Author(s):  
Daniel A. Beard ◽  
James B. Bassingthwaighte

ChemInform ◽  
2010 ◽  
Vol 28 (27) ◽  
pp. no-no
Author(s):  
F. ROSOWSKI ◽  
A. HORNUNG ◽  
O. HINRICHSEN ◽  
D. HEREIN ◽  
M. MUHLER ◽  
...  

Author(s):  
Anna L. Ziff ◽  
Robert M. Ziff

AbstractWe give an update to the original paper posted on 2/17/20 – now (as of 3/1/20) the China deaths are rapidly decreasing, and we find an exponential decline to the power law similar to the that predicted by the network model of Vazquez [2006]. At the same time, we see non-China deaths increasing rapidly, and similar to the early behavior of the China statistics. Thus, we see three stages of the spread of the disease in terms of number of deaths: exponential growth, power-law behavior, and then exponential decline in the daily rate.(Original abstract) The novel coronavirus (COVID-19) continues to grow rapidly in China and is spreading in other parts of the world. The classic epidemiological approach in studying this growth is to quantify a reproduction number and infection time, and this is the approach followed by many studies on the epidemiology of this disease. However, this assumption leads to exponential growth, and while the growth rate is high, it is not following exponential behavior. One approach that is being used is to simply keep adjusting the reproduction number to match the dynamics. Other approaches use rate equations such as the SEIR and logistical models. Here we show that the current growth closely follows power-law kinetics, indicative of an underlying fractal or small-world network of connections between susceptible and infected individuals. Positive deviations from this growth law might indicate either a failure of the current containment efforts while negative deviations might indicate the beginnings of the end of the pandemic. We cannot predict the ultimate extent of the pandemic but can get an estimate of the growth of the disease.


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