Corrigendum to: Structural Variations to the 9-N-Methyladeninium Diterpenoid Hybrid Commonly Isolated from Agelas Sponges

Four novel 9-N-methyladeninium diterpenoids, agelasine M (3), 2-oxo-agelasine B (4), gelasine A (5), and gelasine B (6) accompanied by the known-agelasine B (1) and F (2) were isolated from the marine sponge Agelas sp. collected in Papua New Guinea. Compounds 3?6 represent higher unsaturated 9-N-methyladeninium bicyclic diterpenoid derivatives including 5 and 6 as unusual norditerpenoid-agelasines. Their structures were elucidated through detailed physical data analyses and comparison with literature properties. All pure compounds were evaluated for inhibitory activity against Trypanosoma brucei as well as for cytotoxicity against Jurkat cells.

Download Full-text

Structural Variations to the 9-N-Methyladeninium Diterpenoid Hybrid Commonly Isolated from Agelas Sponges

Australian Journal of Chemistry ◽

10.1071/ch10036 ◽

2010 ◽

Vol 63 (6) ◽

pp. 915 ◽

Cited By ~ 17

Author(s):

Laurent Calcul ◽

Karen Tenney ◽

Joseline Ratnam ◽

James H. McKerrow ◽

Phillip Crews

Keyword(s):

Papua New Guinea ◽

Trypanosoma Brucei ◽

Marine Sponge ◽

Inhibitory Activity ◽

New Guinea ◽

Jurkat Cells ◽

Structural Variations ◽

Data Analyses ◽

Pure Compounds ◽

Agelasine B

Four novel 9-N-methyladeninium diterpenoids, agelasine M (3), 2-oxo-agelasine B (4), gelasine A (5), and gelasine B (6) accompanied by the known-agelasine B (1) and F (2) were isolated from the marine sponge Agelas sp. collected in Papua New Guinea. Compounds 3–6 represent higher unsaturated 9-N-methyladeninium bicyclic diterpenoid derivatives including 5 and 6 as unusual norditerpenoid-agelasines. Their structures were elucidated through detailed physical data analyses and comparison with literature properties. All pure compounds were evaluated for inhibitory activity against Trypanosoma brucei as well as for cytotoxicity against Jurkat cells.

Download Full-text

Antineoplastic agents. Part 395.1 Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp.

Chemical Communications ◽

10.1039/a902380a ◽

1999 ◽

pp. 915-916 ◽

Cited By ~ 19

Author(s):

George R. Pettit ◽

Jun-ping Xu ◽

Diane E. Gingrich ◽

Michael D. Williams ◽

Dennis L. Doubek ◽

...

Keyword(s):

Papua New Guinea ◽

Marine Sponge ◽

Antineoplastic Agents ◽

New Guinea

Download Full-text

Ceratamines A and B, Antimitotic Heterocyclic Alkaloids Isolated from the Marine Sponge Pseudoceratina sp. Collected in Papua New Guinea.

ChemInform ◽

10.1002/chin.200415188 ◽

2004 ◽

Vol 35 (15) ◽

Author(s):

Emiliano Manzo ◽

Rob van Soest ◽

Lohi Matainaho ◽

Michel Roberge ◽

Raymond J. Andersen

Keyword(s):

Papua New Guinea ◽

Marine Sponge ◽

New Guinea

Download Full-text

Identification of bacteria associated with a disease affecting the marine sponge Ianthella basta in New Britain, Papua New Guinea

Marine Ecology Progress Series ◽

10.3354/meps324139 ◽

2006 ◽

Vol 324 ◽

pp. 139-150 ◽

Cited By ~ 48

Author(s):

JM Cervino ◽

K Winiarski-Cervino ◽

SW Polson ◽

T Goreau ◽

GW Smith

Keyword(s):

Papua New Guinea ◽

Marine Sponge ◽

New Guinea ◽

Identification Of Bacteria ◽

New Britain

Download Full-text

ChemInform Abstract: Isolation, Structural Elucidation, and Absolute Stereochemistry of Enigmazole A, a Cytotoxic Phosphomacrolide from the Papua New Guinea Marine Sponge Cinachyrella enigmatica.

ChemInform ◽

10.1002/chin.201052204 ◽

2010 ◽

Vol 41 (52) ◽

pp. no-no

Author(s):

Naoya Oku ◽

Kentaro Takada ◽

Richard W. Fuller ◽

Jennifer A. Wilson ◽

Megan L. Peach ◽

...

Keyword(s):

Papua New Guinea ◽

Marine Sponge ◽

New Guinea ◽

Structural Elucidation ◽

Absolute Stereochemistry

Download Full-text

Traditional Preparations and Methanol Extracts of Medicinal Plants from Papua New Guinea Exhibit Similar Cytochrome P450 Inhibition

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2016/7869710 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Erica C. Larson ◽

Christopher D. Pond ◽

Prem P. Rai ◽

Teatulohi K. Matainaho ◽

Pius Piskaut ◽

...

Keyword(s):

Drug Therapy ◽

Medicinal Plants ◽

Papua New Guinea ◽

Inhibitory Activity ◽

Liver Microsomes ◽

New Guinea ◽

Current Work ◽

Methanol Extracts ◽

Fresh Plant

The hypothesis underlying this current work is that fresh juice expressed from Papua New Guinea (PNG) medicinal plants (succus) will inhibit human Cytochrome P450s (CYPs). The CYP inhibitory activity identified in fresh material was compared with inhibition in methanol extracts of dried material. Succus is the most common method of traditional medicine (TM) preparation for consumption in PNG. There is increasing concern that TMs might antagonize or complicate drug therapy. We have previously shown that methanol extracts of commonly consumed PNG medicinal plants are able to induce and/or inhibit human CYPsin vitro. In this current work plant succus was prepared from fresh plant leaves. Inhibition of three major CYPs was determined using human liver microsomes and enzyme-selective model substrates. Of 15 species tested, succus from 6/15 was found to inhibit CYP1A2, 7/15 inhibited CYP3A4, and 4/15 inhibited CYP2D6. Chi-squared tests determined differences in inhibitory activity between succus and methanol preparations. Over 80% agreement was found. Thus, fresh juice from PNG medicinal plants does exhibit the potential to complicate drug therapy in at risk populations. Further, the general reproducibility of these findings suggests that methanol extraction of dried material is a reasonable surrogate preparation method for fresh plant samples.

Download Full-text